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Abstract Objectives To develop and evaluate a deep learning model for diagnosing untreated rheumatoid arthritis (RA) using digital camera images of bilateral dorsal hands, benchmarking its performance against the widely-...

Abstract Background The newly discovered Treg subset (CLA+ Tregs) expressing cutaneous lymphocyte-associated antigen is associated with inflammatory conditions. This study elucidated the role of CLA+ Tregs in rheumatoid ...

Abstract Juvenile idiopathic arthritis (JIA) comprises a heterogeneous group of childhood-onset inflammatory arthritides that remain challenging to treat. An expanding range of biologic and targeted synthetic disease-mod...

Abstract Background The dysfunction of osteoblasts has been identified as a pivotal contributor to bone erosion in rheumatoid arthritis (RA). Emerging evidence shows long non-coding RNAs (lncRNAs) as important regulators...

Abstract Background Musculoskeletal diseases, such as Juvenile Idiopathic Arthritis (JIA), can lead to altered joint mobility and changes in gait pattern. While marker-based motion capture systems are considered the gold...

Abstract Juvenile idiopathic arthritis (JIA) is an umbrella term for a group of oligo- and poly-arthritic conditions that develop before 16 years of age. While the exact pathophysiology of JIA is still unknown, both gene...

Abstract Background and hypothesis CD5L is a glycoprotein induced during inflammation and makes a life-saving contribution in infection and sepsis. Here, we explored the immunomodulatory effect of CD5L in rheumatoid arth...

Abstract Background Periodontal disease exhibits bidirectional associations with autoimmune diseases; however, comprehensive histological, radiographic, and correlational differences in periodontal tissues between patien...

Abstract Background Mycoplasma hyosynoviae arthritis contributes to antimicrobial use and reduced welfare in fattening pig production. No commercial vaccines are available, and the efficacy of autogenous vaccines remains...

Abstract Background Acute hepatic porphyria (AHP) is a heme metabolism disorder characterized by acute abdominal pain episodes, with diagnostic delays and misdiagnosis due to heterogeneous presentations and symptom overl...

Abstract Background Autoimmune conditions are common in women of reproductive age. They are associated with an increased risk of adverse pregnancy outcomes; whether this is causal is unclear. Our aim was to explore the c...

Abstract Autoimmune diseases (AIDs) result from intricate interactions among genetic, environmental and immune factors, with emerging evidence underscoring the role of the central nervous system (CNS) in their pathogenes...

Abstract Background A increase in average life expectancy leads us to an older population with multimorbidity. Understanding their self-care needs is essential for a response that promotes self-care with better health ou...

Abstract Background and Objective Children with rheumatic diseases experience social determinants of health that influence access to care and outcomes, yet data in pediatric rheumatology are limited. We aimed to characte...

Abstract Background While Canadian First Nations communities actively participate in sport, cultural, and land-based activities, they face various barriers to physical activity. Despite calls for increased support at all...

Abstract Objectives To evaluate the prevalence, associated factors, and prognostic performance of NIH activity index–defined interstitial inflammation (NIH-TII) and interstitial fibrosis and tubular atrophy (IFTA) in l...

Abstract Objectives IgG4-related disease (IgG4-RD) is an immune-mediated condition with diagnostic challenges in clinical practice. Sensitive biomarkers are needed for diagnosis, disease activity and disease progression ...

Abstract Background Lupus retinopathy (LR) is a sight-threatening complication of systemic lupus erythematosus (SLE), yet disease-specific serologic biomarkers are lacking. Previous studies have shown that anti-recoverin...

Abstract Background Lupus nephritis (LN) is a common and severe manifestation of systemic lupus erythematosus (SLE). We sought to evaluate treatment patterns, treat-to-target state attainment, and outcomes of patients wi...