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Abstract Parasitic diseases such as malaria, leishmaniasis, and schistosomiasis remain difficult to treat due to the pathogens’ complex life cycles, intracellular niches, and resistance to conventional therapies. Tradi...

Abstract Background Hypertension is a leading cause of cardiovascular mortality in Nigeria, with a high burden in the Northwest. Effective management at the primary healthcare (PHC) level is critical, yet data on healthc...

Abstract Objectives This dataset was specifically collected to support the development and evaluation of computer-aided diagnosis (CAD) systems for breast cancer detection. The dataset, Ma’amon Diagnostic Center Mammog...

Abstract Background Tuberculosis remains a major public health challenge in Somalia, where a fragile health system and reliance on private providers complicate care. Although Public-Private Partnerships are globally reco...

Abstract Background Disordered eating behaviors are prevalent among children and adolescents with overweight and obesity but are frequently overlooked or underrecognized. We performed a scoping review to identify and map...

Abstract Background This study aims to characterize the clinicopathological and immunophenotypic profile of calcifying fibrous tumor (CFT) occurring in the thoracic cavity, and to elucidate its key diagnostic features fo...

Abstract Transmissible spongiform encephalopathies, or prion diseases, are fatal neurodegenerative diseases that are medically, economically, and ecologically important. In livestock and wildlife, detection to prevent in...

Abstract Background Primary pulmonary lymphoepithelial carcinoma (PPLEC) is an extremely rare subtype of lung squamous cell carcinoma (LUSC). This study aims to comprehensively characterize clinicopathological and molecu...

Abstract Background With the widespread adoption of percutaneous coronary intervention (PCI), patients experiencing acute myocardial infarction (AMI) complicated by ventricular arrhythmia (VA) continue to encounter a sig...

Abstract Background To evaluate the efficacy of an Internet-based Cognitive Behavioral Therapy (ICBT) program in improving kinesiophobia, exercise adherence, pain intensity, lumbar function, and spinal alignment paramete...

Abstract Background Acetabular fractures, predominantly caused by high-energy trauma, pose a substantial healthcare burden in low- and middle-income countries (LMICs) such as Nepal. This study aimed to characterize the e...

Abstract Niclosamide (NA) is widely used as an insecticide in agriculture and fisheries; however, its excessive application poses potential risks to food security and aquatic ecosystems. In this study, halloysite nanotub...

Abstract Background Obesity in adults over 65 years is increasingly prevalent and linked to comorbidities like type 2 diabetes (T2D), hypertension (HTN), osteoarthritis (OA), and obstructive sleep apnea (OSA), where cons...

Abstract Background Current guidelines recommend baseline insulin as the standard treatment for most people hospitalised with type 2 diabetes (PWT2D). However, they generally discourage the use of sodium–glucose cotran...

Abstract Background Radiation-induced sarcoma (RIS) is a rare, fatal late complication of radiotherapy for nasopharyngeal carcinoma (NPC), particularly in the anatomically complex skull base region. Despite the high radi...

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition characterized by hepatic fat accumulation and systemic metabolic dysfunction. MASLD exhibits clear sex differenc...

Abstract Background Thiamine (vitamin B1), a cofactor in energy metabolism and antioxidant pathways, may mitigate mitochondrial dysfunction in critical illnesses. However, its association with outcomes in acute respirato...

Abstract Objective Medical education aims to prepare future physicians for high-quality patient care. This prospective study examines the perceptions of medical students and clinical teachers with regard to teaching in o...

Abstract Background/Objectives Dilated cardiomyopathy (DCM) is characterized by heart failure and cardiac dilation, distinguishing it from ischemic and non-ischemic heart diseases. To date, more than 50 genes have been i...

Abstract Background Endoscopic vidian neurectomy has been performed for decades on patients with refractory allergic rhinitis and vasomotor rhinitis. Although the surgical approach has evolved continuously, it still has ...

Abstract Background Sphincter preservation (SP) during laparoscopic total mesorectal excision (LaTME) for low rectal cancer is challenged by a deep, narrow pelvis. Robust, MRI-based predictors for both SP success and ope...

Abstract Objective Eating disorders (ED) are most prevalent in women of reproductive age. EDs affect fertility, maternal BMI, and obstetric outcomes. During the early postpartum period, women with an ED history are at hi...

Abstract The core pathological mechanisms of diabetic microvascular diseases, such as nephropathy, diabetic retinopathy (DR), and neuropathy, involve the dysfunction and loss of microvascular endothelial cells (ECs), vas...

Abstract Automobile cabin air filter-deposited particulate matter represents an underappreciated exposure source, yet the differential toxicity between filter sides and underlying mechanisms remain unclear. Here, we syst...