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Abstract Studying microbial biodiversity offers enormous potential for improving the valorisation of plant biomass, particularly in conversion processes. Microorganisms, such as bacteria, fungi, yeasts and algae, play an...

Abstract Background Tuberculosis (TB) remains a critical global public health issue, particularly in rapidly urbanizing regions where population density and migration facilitate transmission. While whole-genome sequencin...

Abstract Transcriptome sequencing data offer a valuable resource for inferring genetic variants, yet their application in forensic individual identification and kinship analysis remains insufficiently explored. This stud...

Abstract Background Burkholderia pseudomallei, the causative agent of melioidosis, infects both humans and a broad range of animal species. While human disease has been well characterized, animal data are dispersed acros...

Abstract Background Venom cocktails of cone snails are characterized by their dynamic composition and the rapid evolution of toxin-encoding genes due to various selective pressures. The integration of comparative genomic...

Abstract Background Antenatal hydronephrosis (AHN) is a common urological abnormality identified during prenatal ultrasound examination, with heterogeneous underlying causes. This study aimed to investigate the genetic e...

Abstract Background Comprehensive genomic analysis and optimal treatment for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) G719X + S768I co-mutations remain limited. This st...

Abstract Background Preeclampsia (PE), a life-threatening hypertensive disorder of pregnancy, remains poorly characterized at the post-transcriptional regulation level. While alternative splicing (AS) perturbations drive...

Abstract Background Understanding the genetic evolution of HIV-1 Transmitted/Founder (T/F) virus is crucial for developing effective treatment and prevention strategies due to its rapid mutation and recombination rates. ...

Abstract Background Tenacious glume a key trait limiting threshing efficiency in synthetic hexaploid wheat (SHW), represents an ancestral defense mechanism inherited from wild progenitors. Despite its evolutionary import...

Abstract Deoxynivalenol (DON), a prevalent Fusarium mycotoxin, poses a significant threat to intestinal health in piglets. This study established a deoxynivalenol (DON) intoxication model in piglets, revealing compromise...

Abstract Background An in-depth analysis was conducted on the mitochondrial genomes of three newly introduced Terebelliformia species (Amaeana sp., Terebellides sp.A and Terebellides sp.B), focusing on their genomic feat...

Abstract Freshwater adaptation from marine ancestors represents a major ecological transition in teleost evolution, yet its genomic basis remains poorly understood. The genus Brachirus is predominantly marine, although a...

Abstract Objective Streptococcus shenyangsis is a recently reported member of the genus Streptococcus, rarely detected in the human oral cavity and for which genomic information remains limited. To broaden our understand...

Abstract The genomic locus that encodes the Leucine-rich repeat kinase 2 (LRRK2) gene is highly pleiotropic and associated with Parkinson’s disease (PD). Coding variants associated with risk of PD act as gain of functi...

Abstract Background Melissa officinalis (balm) is a perennial medicinal. Climate change and high cultivation costs necessitate the breeding of new cultivars with improved stress tolerance and high metabolite content. How...

Abstract Background The emergence of tmexCD-toprJ, a plasmid-mediated resistance-nodulation-division efflux pump gene cluster conferring resistance to tigecycline, poses a critical public health threat. While its prevale...

Abstract Polyunsaturated fatty acids (PUFAs) are important nutrients that play critical roles in sea urchin reproduction and early development. Strongylocentrotus intermedius, the only commercially cultured sea urchin sp...

Abstract Background The genetic basis of autism spectrum disorder (ASD) is complicated by high heritability and substantial heterogeneity, in which de novo variants and polygenic burden from common variants have not been...

Abstract Background Super-enhancers are critical cis-regulatory elements that play a central role in modulating gene expression and driving cellular identity. Their dysregulation is closely associated with the developmen...

Abstract Background Inflammatory bowel disease (IBD) represents a group of chronic and relapsing inflammatory disorders of the gastrointestinal tract, primarily encompassing Crohn’s disease (CD) and ulcerative colitis ...

Abstract Background Zanthoxylum armatum is a vital economic crop in China, but its cultivation is challenged by abiotic stresses like drought and cold. Mitogen-activated protein kinase kinases (MAPKKs) are central signal...

Abstract Background Prolificacy is a crucial economic trait in goat production, yet its underlying molecular mechanisms remain incompletely understood due to its polygenic nature. While previous studies have identified s...