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23 resultados encontrados.

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Serum uric acid-to-HDL-C ratio as an independent predictor of metabolic syndrome in the elderly: diagnostic model optimization and inflammatory mechanism insights
Artículo
Acceso abierto Artículo DOAJ
Serum uric acid-to-HDL-C ratio as an independent predictor of metabolic syndrome in the elderly: diagnostic model optimization and inflammatory mechanism insights
Runfeng Sun et al · BMC · 2026 · ISSN 1471-2318
Abstract Objective This study aimed to investigate the independent predictive value of the uric acid-to-HDL-C ratio (UHR) for metabolic syndrome (MS) in the elderly, develop an optimized diagnostic model, and assess whet...
LCC TENDOkdlcmlhdHJpY3M~Idioma eng
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The obesity-brain axis: a comprehensive review of neurological complications and therapeutic interventions in metabolic syndrome
Artículo
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The obesity-brain axis: a comprehensive review of neurological complications and therapeutic interventions in metabolic syndrome
Amin Roshdy Soliman et al · BMC · 2026 · ISSN 1758-5996
Abstract Background Obesity has emerged as a major global health issue, affecting multiple organ systems. Within the central nervous system obesity causes a series of disruptions that can significantly affect neurologica...
LCC LCC:Nutritional diseases. Deficiency diseasesIdioma eng
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Urinary GC–MS metabolomics reveals pregnancy-associated metabolic reprogramming and biomarkers in buffaloes
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Urinary GC–MS metabolomics reveals pregnancy-associated metabolic reprogramming and biomarkers in buffaloes
Pooja Doshi et al · BMC · 2026 · ISSN 1746-6148
Abstract Background Timely and accurate pregnancy detection in the dairy animals is essential for minimizing calving intervals to accelerate reproductive turnover and increase milk production from livestock farming. Urin...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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An exploratory study of glycemic biomarkers and rTMS treatment outcomes in treatment-resistant depression
Artículo
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An exploratory study of glycemic biomarkers and rTMS treatment outcomes in treatment-resistant depression
Dara Silver et al · BMC · 2026 · ISSN 1471-244X
Abstract Background Repetitive transcranial magnetic stimulation (rTMS) is an efficacious therapy for treatment-resistant depression (TRD) and is thought to drive neuroplastic changes in affective networks. However, up t...
LCC TENDOlBzeWNoaWF0cnk~Idioma eng
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Global and regional prevalence, burden, and risk factors for MASLD in children and adolescents aged 5 to 24 years: a systematic review, meta-analysis, and modeling study
Artículo
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Global and regional prevalence, burden, and risk factors for MASLD in children and adolescents aged 5 to 24 years: a systematic review, meta-analysis, and modeling study
Yunfei Liu et al · BMC · 2026 · ISSN 1741-7015
Abstract Background Obesity is associated with metabolic dysfunction-associated steatotic liver disease (MASLD). Despite the rising prevalence of obesity among children and adolescents, no studies have examined risk fact...
LCC LCC:MedicineIdioma eng
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OneSTOP (One-Stop Telehealth Obesity Program): study protocol for an open-label randomized controlled trial on the use of telecare and digital platforms for multidisciplinary management of weight management and related comorbidities
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OneSTOP (One-Stop Telehealth Obesity Program): study protocol for an open-label randomized controlled trial on the use of telecare and digital platforms for multidisciplinary management of weight management and related comorbidities
Joan Khoo et al · BMC · 2026 · ISSN 1745-6215
Abstract Background Obesity is prevalent in Singapore and is a driver of multiple co-morbidities including type 2 diabetes, metabolic dysfunction associated steatotic liver disease (MASLD), and cardiovascular disease. Tr...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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The association between the triglyceride-glucose index and serum uric acid: a systematic review and meta-analysis
Artículo
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The association between the triglyceride-glucose index and serum uric acid: a systematic review and meta-analysis
Lanlan Feng et al · BMC · 2026 · ISSN 1472-6823
Abstract Background The triglyceride-glucose (TyG) index has emerged as a surrogate marker for insulin resistance. This systematic review and meta-analysis of observational studies aimed to investigate the association be...
LCC LCC:Diseases of the endocrine glands. Clinical endocrinologyIdioma eng
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Beyond the known: prospective research directions for the gut-brain axis in obesity and type 1 diabetes mellitus
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Beyond the known: prospective research directions for the gut-brain axis in obesity and type 1 diabetes mellitus
DuJiang Yang et al · BMC · 2026 · ISSN 1758-5996
Abstract Background This letter engages with the seminal review by Argyrakopoulou et al. Obesity and the Gut-Brain Axis in Type 1 Diabetes Mellitus: Terra Incognita? Curr Obes Rep, https://doi.org/10.1007/s13679-025-0065...
LCC LCC:Nutritional diseases. Deficiency diseasesIdioma eng
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Chromosome-level genome provides new insights into the fatty acid biosynthesis and metabolism of the sea urchin Strongylocentrotus intermedius
Artículo
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Chromosome-level genome provides new insights into the fatty acid biosynthesis and metabolism of the sea urchin Strongylocentrotus intermedius
Lingshu Han et al · BMC · 2026 · ISSN 1471-2164
Abstract Polyunsaturated fatty acids (PUFAs) are important nutrients that play critical roles in sea urchin reproduction and early development. Strongylocentrotus intermedius, the only commercially cultured sea urchin sp...
LCC TENDOkJpb3RlY2hub2xvZ3k~; LCC:GeneticsIdioma eng
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Cohort profile of the first 2,000 canine enrolees in the Mars Petcare Biobank: demographic, hematologic and serum biochemistry results from March 2022 to December 2024
Artículo
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Cohort profile of the first 2,000 canine enrolees in the Mars Petcare Biobank: demographic, hematologic and serum biochemistry results from March 2022 to December 2024
Janet E. Alexander et al · BMC · 2026 · ISSN 1746-6148
Abstract Background The MARS PETCARE BIOBANK™ (MPB) is a study recruiting pets visiting Mars Veterinary Health hospitals in the USA over a ten-year period, with the aim of analysing longitudinal data from thousands of ...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Complete genome sequence of Streptococcus shenyangsis isolated from buccal mucosa
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Complete genome sequence of Streptococcus shenyangsis isolated from buccal mucosa
Seok Bin Yang et al · BMC · 2026 · ISSN 2730-6844
Abstract Objective Streptococcus shenyangsis is a recently reported member of the genus Streptococcus, rarely detected in the human oral cavity and for which genomic information remains limited. To broaden our understand...
LCC LCC:GeneticsIdioma eng
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Extracellular vesicles derived from live or apoptotic mesenchymal stem cells: comparison of the effects of two extracellular vesicles on liver fibrosis
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Extracellular vesicles derived from live or apoptotic mesenchymal stem cells: comparison of the effects of two extracellular vesicles on liver fibrosis
Ruobing Ju et al · BMC · 2026 · ISSN 1471-230X
Abstract Background Mesenchymal stem cells (MSCs) have become a promising treatment of liver fibrosis which is a key process in liver diseases. Recent studies have shown that transplanted MSCs undergo rapid apoptosis and...
LCC LCC:Diseases of the digestive system. GastroenterologyIdioma eng
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Identification of common genetic and molecular signatures in migraine and comorbid conditions
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Identification of common genetic and molecular signatures in migraine and comorbid conditions
Zitong Huang et al · BMC · 2026 · ISSN 1129-2377
Abstract Background Migraine is a very common chronic neurological disorder associated with severe disability and significant social burden worldwide. Beyond recurrent headache attacks, increasing evidence indicates that...
LCC LCC:MedicineIdioma eng
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Long-term 3D culture of human cumulus granulosa cell spheroids in PEGylated fibrin: a preclinical model for reproduction and ovarian research
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Long-term 3D culture of human cumulus granulosa cell spheroids in PEGylated fibrin: a preclinical model for reproduction and ovarian research
Maria João Sousa et al · BMC · 2026 · ISSN 1757-2215
Abstract Background Cumulus granulosa cells (CGCs) are essential for oocyte support, metabolic cooperation, and steroidogenesis, yet they deteriorate rapidly in conventional 2D culture, limiting long-term studies of thes...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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Multi-omics analysis reveals the critical role of gut microbiota related tryptophan and glutathione metabolism in sepsis-associated encephalopathy
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Multi-omics analysis reveals the critical role of gut microbiota related tryptophan and glutathione metabolism in sepsis-associated encephalopathy
Xiaomin Hu et al · BMC · 2026 · ISSN 1471-2180
Abstract Background Recent studies highlight the critical role of gut microbiota in sepsis pathogenesis and its potential link to neurological disorders, particularly sepsis-associated encephalopathy (SAE). However, the ...
LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
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Oxidative stress and the therapeutic potential of dietary antioxidants in polycystic ovary syndrome: a narrative review
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Oxidative stress and the therapeutic potential of dietary antioxidants in polycystic ovary syndrome: a narrative review
Nevin Adel Amer et al · BMC · 2026 · ISSN 1757-2215
Abstract It is becoming more well acknowledged that oxidative stress is a crucial component that connects the hormonal, metabolic, and reproductive aspects of polycystic ovarian syndrome (PCOS). A more holistic and natur...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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Precision immunotherapy for head and neck cancer: therapeutic combinations, biomarker strategies, and translational challenges
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Precision immunotherapy for head and neck cancer: therapeutic combinations, biomarker strategies, and translational challenges
Kohei Okuyama et al · BMC · 2026 · ISSN 1476-4598
Abstract Immune checkpoint inhibitors (ICIs) have fundamentally altered the therapeutic paradigm for head and neck squamous cell carcinoma (HNSCC); however, durable clinical benefit remains limited to biologically define...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons
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Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons
Konstantina Chanoumidou et al · BMC · 2026 · ISSN 1757-6512
Abstract Background Hyperglycemia, a hallmark of diabetes mellitus, is a metabolic condition that highly affects the nervous system. While evidence from epidemiological and animal studies links diabetes to dopaminergic d...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; TENDOkJpb2NoZW1pc3RyeQ~~Idioma eng
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The double-edged sword role of tumor-associated macrophages: preventing or causing resistance to immunotherapy
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The double-edged sword role of tumor-associated macrophages: preventing or causing resistance to immunotherapy
Raheleh Roudi et al · BMC · 2026 · ISSN 1756-9966
Abstract Immunotherapy has transformed cancer treatment, yet only a subset of patients achieves durable responses. Although macrophages play a key role in modulating immune response and could be used to enhance immunothe...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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The interplay between Peptostreptococcus and Fusobacterium as novel signatures in colorectal cancer recurrence
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The interplay between Peptostreptococcus and Fusobacterium as novel signatures in colorectal cancer recurrence
Yunhui Zhang et al · BMC · 2026 · ISSN 2049-2618
Abstract Background After resection surgery, recurrence occurs in more than 30% of colorectal cancer (CRC) patients. Previous studies have highlighted the role of the gut microbiota in CRC initiation and progression; how...
LCC LCC:Microbial ecologyIdioma eng
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The vitamin D-cardiovascular nexus unraveling mechanistic promise and trial reality
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The vitamin D-cardiovascular nexus unraveling mechanistic promise and trial reality
Hui Xu · BMC · 2026 · ISSN 1743-7075
Abstract Background Epidemiological data consistently associate low vitamin D status with elevated cardiovascular risk, yet causal mechanisms remain contested. Methods This review synthesized evidence through a protocol-...
LCC LCC:Nutrition. Foods and food supply; LCC:Nutritional diseases. Deficiency diseasesIdioma eng
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A decade of InsulinAPP: validation using COSMIN and clinical advancements since its initial publication
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A decade of InsulinAPP: validation using COSMIN and clinical advancements since its initial publication
Toyoshima Marcos Tadashi Kakitani et al · BMC · 2025 · ISSN 1758-5996
Abstract This correspondence marks the 10-year milestone of InsulinAPP, a Brazilian-developed electronic glycemic management system (eGMS) designed to support inpatient insulin therapy. Initially published in 2015, Insul...
LCC LCC:Nutritional diseases. Deficiency diseasesIdioma eng
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Efficacy and safety of external phytotherapy in diabetic foot ulcers: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials
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Efficacy and safety of external phytotherapy in diabetic foot ulcers: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials
Xiaodan Yan et al · BMC · 2026 · ISSN 1758-5996
Abstract Background Diabetic Foot Ulcers (DFUs) represent a global healthcare challenge, imposing substantial socioeconomic burdens due to their increasing incidence and associated mortality. This study evaluates the eff...
LCC LCC:Nutritional diseases. Deficiency diseasesIdioma eng
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