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Abstract Background Iron overload promotes atherosclerosis in mice and causes vascular dysfunction in humans with Hemochromatosis. However, data are controversial on whether systemic iron availability within physiologica...

Abstract Background Environmental studies often evaluate how exposures influence health outcomes through intermediate biological processes. In practice, researchers are often interested in complex exposure mixtures rathe...

Abstract Background Optimization of biotechnological processes is traditionally limited by time-consuming trial-and-error approaches and the complexity of simultaneously optimizing multiple, often conflicting objectives....

Abstract Background Outcomes after curative-intent sarcoma surgery vary substantially and are incompletely explained by tumor-centered factors alone. Although CT-based body composition metrics provide objective host-rela...

Abstract Background Systemic inflammation and nutritional status are increasingly recognized as prognostic determinants in glioblastoma (GBM). The CRP–albumin–lymphocyte (CALLY) index integrates inflammatory and immu...

Abstract Background Protein-protein interaction (PPI) network-based protein function prediction algorithms, which use the guilt-by-association principle, are widely applied in medical and human domains, but they are comp...