NODOVOX | Discovery

Clinical characterization and structural modeling of a novel de novo SPTBN1 missense variant in a Chinese child

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Clinical characterization and structural modeling of a novel de novo SPTBN1 missense variant in a Chinese child

Junyu Wang et al · BMC · 2026 · ISSN 1471-2431

Abstract Background SPTBN1 encodes βII-spectrin, a cytoskeletal protein essential for neuronal structure and function. Pathogenic variants in this gene cause a neurodevelopmental disorder known as DDISBA (Developmental ...

LCC TENDOlBlZGlhdHJpY3M~Idioma eng

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A modular clinical thinking navigation system: an exploration in the ‘101 Project’ diagnostics textbook reform

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A modular clinical thinking navigation system: an exploration in the ‘101 Project’ diagnostics textbook reform

Rong Bi et al · BMC · 2026 · ISSN 1472-6920

Abstract The global challenge of effectively cultivating clinical thinking in medical students persists, often hindered by traditional textbooks that present knowledge in a linear sequence disconnected from the non-linea...

LCC TENDOlNwZWNpYWwgYXNwZWN0cyBvZiBlZHVjYXRpb24~; LCC:MedicineIdioma eng

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Anticancer activity of an apigenin-functionalized silica-coated silver oxide nanocomposite against human gastric adenocarcinoma cells (AGS): in vitro and in silico analysis

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Anticancer activity of an apigenin-functionalized silica-coated silver oxide nanocomposite against human gastric adenocarcinoma cells (AGS): in vitro and in silico analysis

Seyed Milad Mousavi Eshkelani et al · BMC · 2026 · ISSN 1472-6750

Abstract Silver nanoparticles show promise anticancer agents, yet their clinical translation is hindered by poor bioavailability and nonspecific toxicity. In this study, we developed an apigenin-functionalized silica-coa...

LCC TENDOkJpb3RlY2hub2xvZ3k~Idioma eng

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Clustering-based low-rank matrix approximation for multimodal medical image compression

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Clustering-based low-rank matrix approximation for multimodal medical image compression

Sisipho Hamlomo et al · BMC · 2026 · ISSN 1756-0381

Abstract Medical images are inherently high-resolution and contain locally varying structures that are crucial for diagnosis. Efficient compression of such data must therefore preserve diagnostic fidelity while minimizin...

LCC TENDOkNvbXB1dGVyIGFwcGxpY2F0aW9ucyB0byBtZWRpY2luZS4gTWVkaWNhbCBpbmZvcm1hdGljcw~~; LCC:AnalysisIdioma eng

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Long-term 3D culture of human cumulus granulosa cell spheroids in PEGylated fibrin: a preclinical model for reproduction and ovarian research

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Long-term 3D culture of human cumulus granulosa cell spheroids in PEGylated fibrin: a preclinical model for reproduction and ovarian research

Maria João Sousa et al · BMC · 2026 · ISSN 1757-2215

Abstract Background Cumulus granulosa cells (CGCs) are essential for oocyte support, metabolic cooperation, and steroidogenesis, yet they deteriorate rapidly in conventional 2D culture, limiting long-term studies of thes...

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Shexiang Tongxin Dropping Pills targeting Piezo1/Ca2+/NLRP3 axis attenuates vascular endothelial inflammation

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Shexiang Tongxin Dropping Pills targeting Piezo1/Ca2+/NLRP3 axis attenuates vascular endothelial inflammation

Jingya Liu et al · BMC · 2026 · ISSN 1749-8546

Abstract Background Vascular endothelial inflammation is a key pathological process underlying various inflammatory vascular conditions, which can lead to severe cardiovascular complications. Shexiang Tongxin Dropping Pi...

LCC TENDOk90aGVyIHN5c3RlbXMgb2YgbWVkaWNpbmU~Idioma eng

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The Turkish adaptation of the Child Occupational Self-Assessment Scale (COSA) and its psychometric properties in children with attention-deficit/hyperactivity disorder

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The Turkish adaptation of the Child Occupational Self-Assessment Scale (COSA) and its psychometric properties in children with attention-deficit/hyperactivity disorder

Damla Ece Irmak et al · BMC · 2026 · ISSN 2050-7283

Abstract Background Occupational therapy practices are expanding in Turkey; however, pediatric professionals lack validated, client-centered assessment instruments for children with attention-deficit/hyperactivity disord...

LCC TENDOlBzeWNob2xvZ3k~Idioma eng

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Cerebrovascular claudin-5 isoform expression correlates with worsened stroke outcomes following thromboembolic stroke

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Cerebrovascular claudin-5 isoform expression correlates with worsened stroke outcomes following thromboembolic stroke

Trevor S. Wendt et al · BMC · 2026 · ISSN 2045-8118

Abstract Background and purpose Claudin-5 plays a crucial role in maintaining blood-brain barrier (BBB) integrity through endothelial tight junction formation. Alternative splicing of claudin-5 within the microvascular e...

LCC LCC:Neurology. Diseases of the nervous systemIdioma eng

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Protein structure and selection pressure in plants: using mutation to understand the functional importance of protein structure

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Protein structure and selection pressure in plants: using mutation to understand the functional importance of protein structure

Evan Long et al · BMC · 2026 · ISSN 1471-2164

Abstract Recent advances in protein structure prediction have opened new avenues for understanding the potential impact of genetic mutations and how they might affect protein structure. In this study, we analyzed the dis...

LCC TENDOkJpb3RlY2hub2xvZ3k~; LCC:GeneticsIdioma eng

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Reconciling canopy light interception and photosynthetic efficiency to optimize source-sink coordination and yield formation in winter wheat

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Reconciling canopy light interception and photosynthetic efficiency to optimize source-sink coordination and yield formation in winter wheat

Yamiao Zhang et al · BMC · 2026 · ISSN 1471-2229

Abstract Background Optimizing the seeding rate is critical for wheat productivity. However, excessive densification often compromises individual photosynthetic efficiency to maximize canopy light interception, creating ...

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