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ABSTRACT: Objective: To investigate the effects of commonly prescribed antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs) during early life on enamel development through a systematic review with quantitative ...

Endothelial glycocalyx dysregulation remains the leading cause of the development and progression of cardiovascular diseases, which can increase the risk of organ failure and even cause death. However, the construction o...

Drug discovery research faces significant challenges, with around 90 % of candidate drugs failing in clinical trials. Traditional animal models do not always accurately reflect human physiology and pathology, leading to ...

Pain after surgery is of major perioperative concern because it is associated with substantial complications, including chronic post-surgical pain (CPSP) development. The CPSP incidence is high, and its accurate predicti...

Synthesis of new drugs, their rational design, or isolation from natural sources has decreased, and these facts lead to the use of currently marketed drugs. Some of them, extensively used, show unfavorable properties rel...