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BackgroundThe adverse impacts of chronic pain extend far beyond the physical sensation itself. Chronic pain, an age-related condition, exacerbates geriatric disease burden and drives a central sensitivity-neuropsychiatri...

ObjectiveTo develop a Health Action Process Approach (HAPA) based exercise rehabilitation program for chronic heart failure (CHF) patients and evaluate its effectiveness.MethodsA randomized controlled trial was carried o...

BackgroundHeart failure (HF) with chronic arrhythmias is associated with autonomic dysfunction and poor outcomes. Heart rate variability (HRV) reflects autonomic dysfunction and predicts outcomes in HF. This study invest...

Environmental factors such as air pollution, weather events, and ambient toxins are major contributors to human disease, with disproportionate impacts on vulnerable populations. In Puerto Rico, chronic exposure to air po...

ObjectiveTo examine the heterogeneity and determinants of Traditional Chinese Medicine Health Literacy (TCM-HL) among middle-aged and older adults patients with chronic diseases and its association with disease burden an...

BackgroundChronic low back pain (CLBP), with or without radicular pain (RP), is a major cause of disability and reduced quality of life. Psychological comorbidities such as depression, anxiety, and chronic pain disorder ...

Chronic pain affects hundreds of millions worldwide, yet current treatments—from NSAIDs to opioids—fall short and bring unwanted side effects. Neuroinflammation drives bidirectional glial-neuronal communication, a co...

BackgroundDepressive symptoms are common in gastroenterology practice but often missed due to patient stigma and the limitations of self-report questionnaires. This detection gap limits patient access to necessary mental...

Chronic limb disuse during the active growth phase can induce complex secondary deformities, including paradoxical bone overgrowth. A 12-month-old neutered male Toy Poodle presented with non-weight-bearing right forelimb...

Chronic inflammation is a hallmark of many diseases, including persistent viral infections. In human immunodeficiency virus (HIV) infection, sustained immune activation contributes to end-organ damage and non-AIDS comorb...

BackgroundMetabolic syndrome (MetS) affects approximately 1.54 billion adults worldwide and is characterized by central obesity, insulin resistance, hypertension, and dyslipidemia. Chronic low-grade inflammation is cen...

BackgroundThe intestinal barrier is a critical interface between the host and the external environment, and growing evidence indicates that bidirectional crosstalk between the gut microbiota and the intestinal barrier is...