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Materias / palabras clave: diet; dietary factors; gut microbiome; gut microbiota; inflammation; metabolic health

IntroductionAquatic light environments are increasingly altered by human activity, yet the endocrine and molecular mechanisms enabling fish to cope with extreme photoperiods remain poorly understood. This study investiga...

BackgroundEarly detection of diabetic retinopathy (DR) remains challenging in primary care, where access to ophthalmic screening is limited. We developed and validated a prediction model using routinely collected health ...

PurposeProlonged QT intervals are clinically relevant in patients with type 2 diabetes mellitus (T2DM). However, accurately detecting the Q and T points in electrocardiogram (ECG) signals remains challenging owing to the...

IntroductionThe vertebrate nonapeptide vasotocin (Avp) is evolutionarily conserved and homologous to mammalian vasopressin. Previous work using avp-/- zebrafish demonstrated a role for Avp in female, but not male, zebraf...

Midlife represents a biological “phenotype transition” for women, during which sarcopenic obesity risk can rise despite stable BMI. Evidence anchored to the STRAW + 10 framework suggests that the interval surroundi...

IntroductionFamilial partial lipodystrophy (FPL) is a rare condition related to partial deficiency of adipose tissue and consequent insulin resistance resulting in metabolic alterations. Although type 2 diabetes mellitus...

ObjectiveRegarding the exact association between hypothyroidism, levothyroxine replacement and kidney dysfunction, there is a lack of study to summarize the previous evidence. The aim of this study is to explore these re...

Celiac disease (CD) and Hashimoto’s thyroiditis (HT) frequently coexist, suggesting that shared mechanisms of autoimmunity extend beyond the intestine. In CD, the pathogenic role of gluten is firmly established; in HT,...

BackgroundPathogenic variants in melanocortin-4 receptor (MC4R) are the most common cause of nonsyndromic monogenic obesity. However, links between MC4R-related obesity and pubertal tempo, and the long-term endocrine–m...

BackgroundWestern diet (WD) consumption accelerates the development of metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). This study investigated whether chestnut-derived ellagitannins (FT50) modulate early m...

BackgroundThe prevalence of type 2 diabetes is continuously increasing, and optimizing the treatment strategies for diabetes is an important clinical issue. SGLT2 inhibitors (SGLT2i) and DPP-4 inhibitors (DPP-4i) are two...

PurposeThis study aimed to describe the clinicopathological landscape of thyroid disease, summarize long-term management trends of thyroid carcinoma (TC) and lymph node metastasis (LNM) from 1999 to 2018, and develop a n...

BackgroundInterstitial fibrosis and tubular atrophy (IFTA) are key pathological features of chronic kidney damage and progression in diabetic nephropathy (DN). Early identification of patients at higher risk of IFTA may ...

Materias / palabras clave: CKM syndrome; inflammation; management; mechanism; therapy

Materias / palabras clave: bone density; bone metabolism; bone quality; fracture; osteoporosis

IntroductionProbiotics have demonstrated positive effects on obesity and type 2 diabetes (T2D) in various studies. Postbiotics, specifically nonliving bacterial lysates derived from cell walls and DNA, are increasingly r...

IntroductionPolycystic ovary syndrome (PCOS) affects 5–20% of adolescent females worldwide, yet scalable non-pharmacological interventions remain scarce. Tai Chi, a traditional Chinese mind-body exercise, may address t...

Background and objectiveEndothelial dysfunction is a key driver of cardiovascular complications in individuals with impaired glucose tolerance (IGT), with oxidative stress and inflammation playing pivotal roles in its pa...

BackgroundDiabetic peripheral neuropathy (DPN) is a common diabetes complication. Buyang Huanwu Decoction (BYHWD) combined with α-lipoic acid (ALA) is used clinically, but evidence consistency and heterogeneity sources ...

BackgroundGestational diabetes mellitus (GDM) is an increasingly important contributor to maternal and neonatal morbidity in Africa, yet the evidence base remains fragmented across settings and research domains. This stu...

BackgroundHormone-sensitive cancers (HSCs) pose a significant threat to women’s health, with global rising incidence rates. This study provides the most up-to-date assessment of the global burden of HSCs.MethodsWe retr...

PurposePreimplantation genetic testing for aneuploidy (PGT-A) is essential for selecting embryos free from chromosomal abnormalities before transfer. However, challenges such as detection failures, mosaicism, and the lim...

IntroductionDesmoid tumors, also known as aggressive fibromatosis, are rare, locally invasive soft tissue neoplasms characterized by clonal fibroblastic proliferation without metastatic potential. Gamma secretase inhibit...