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Allergic rhinitis (AR), asthma, and their combined allergic rhinitis and asthma syndrome (CARAS) frequently coexist. However, the underlying pathophysiological and metabolic mechanisms, as well as reliable diagnostic dif...

Crabapple (Malus prunifolia (Willd.) Borkh) is valued for its ornamental appearance, effectiveness as a rootstock, and rich nutritional profile. However, the flavor profile and metabolite composition are poorly character...

Parkinson’s disease (PD) is characterized by profound metabolic disturbances in the brain, yet how these alterations vary across brain regions and respond to neuroprotective intervention remains poorly understood. Here...

ObjectivePolycystic ovary syndrome (PCOS) is a complex endocrine disorder. In this study, we characterize serum bile acids (BAs) metabolic profiles in PCOS patients using targeted metabolomics and investigated their corr...

IntroductionGastrodia elata f. glauca represents a superior cultivar of G. elata with considerable commercial value and broad market acceptance. The growth of its tubers and the accumulation of bioactive secondary metabo...

Background and ObjectiveDifferentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) is clinically difficult, especially when patients are seronegative for anti–aquaporin-4 immunoglobulin...

Gastrodia elata Blume, a traditional medicinal plant, the dynamic metabolic changes and the mechanisms underlying the accumulation of medicinal components remain poorly understood during its key developmental stages (tub...

Mitragyna speciosa (commonly known as kratom) is a tropical tree native to Southeast Asia, ethnobotanically used for pain relief and fatigue management. Kratom has gained popularity in Western countries for its dose-depe...

Materias / palabras clave: biodiversity; biosynthetic pathways; functional diversity; metabolomics; multitrophic interactions; phytochemical diversity

BackgroundSarcopenia has a high incidence in older patients with sepsis and is closely associated with poor prognosis, but its metabolic characteristics under this specific stress state remain unclear. This study aims to...

IntroductionLichens are poikilohydric organisms whose biochemistry is strongly shaped by environmental conditions, yet their metabolome-wide adaptations across habitats remain unexplored.MethodsHere, we established a con...

AimTo clarify the molecular mechanisms through which lobetyolin (LT) modifies the gut microbiota-bile acid axis to multitarget the regulation of hyperandrogenism, insulin resistance, chronic low-grade inflammation, and e...

Seed germination is severely constrained by soil salinity, limiting crop establishment in salt-affected agricultural lands. This study investigated whether seed priming with molybdenum nanoparticles (Mo NPs) enhances ger...

Reclaimed backfill solution, a process-derived liquid generated during pedunculated filament treatment in tobacco manufacturing, has potential value for resource recovery and process reuse; however, its storage stability...

IntroductionMetabolism-associated fatty liver disease (MAFLD) has emerged as a severe worldwide public health burden with insufficient available clinical therapeutic strategies, which underscores the urgent demand for sa...

Background and aimsTongxie Yaofang (TXYF) is a classic prescription for IBS-D with liver depression and spleen deficiency, with its therapeutic mechanisms requiring further elucidation. This study investigated the modula...