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Modern animal and crop production practices are associated with the regular use of antimicrobials, potentially increasing selection pressure on bacteria to become resistant. Alternative approaches are needed in order to ...

IntroductionNeutrophils, the most abundant leukocyte population, play a central role in host defense against group B Streptococcus (GBS), an encapsulated bacterium that frequently causes severe infections in humans, incl...

IntroductionThe vertebrate nonapeptide vasotocin (Avp) is evolutionarily conserved and homologous to mammalian vasopressin. Previous work using avp-/- zebrafish demonstrated a role for Avp in female, but not male, zebraf...

IntroductionCyclin-dependent kinase 5 (Cdk5) plays a critical role in pain transmission by phosphorylating key nociceptive proteins. One of its recently identified substrates, the P2X2 subunit, is part of the P2X2/3 puri...

Chronic inflammation is a hallmark of many diseases, including persistent viral infections. In human immunodeficiency virus (HIV) infection, sustained immune activation contributes to end-organ damage and non-AIDS comorb...

Leukocyte immunoglobulin (Ig)-like receptors (LILRs) constitute a family of 11 structurally related receptors predominantly expressed on immune cells. Despite their functional diversity, LILRs show a high degree of seque...