Buscar recursos académicos

Materias / palabras clave: cancer metabolism; cancer therapeutics; drug discovery; precision medicine; targeted therapy

Cancer therapy and food preservation both face significant challenges related to stability, targeted delivery, safety, and efficiency of active compounds. Biopolymer-based nanoparticles, particularly those derived from c...

Despite the success of HER2-targeted antibody-drug conjugates (ADCs) in common cancers, there is a lack of real-world evidence regarding their role in rare tumors where ERBB2 gene amplification by next-generation sequenc...

Materias / palabras clave: cancer therapy; immunogenic cell death; protein kinase inhibitors; signaling pathway; targeted therapy

Targeted B-cell depletion via the anti-CD20 monoclonal antibody rituximab fundamentally altered the therapeutic algorithm for rheumatoid arthritis (RA). Despite its clinical entrenchment, approximately 40% of patients ex...

BackgroundTransarterial chemoembolization (TACE) is a standard treatment for intermediate-stage hepatocellular carcinoma (HCC), but its efficacy varies due to patient heterogeneity. Combining TACE with systemic therapies...

Cancer-associated fibroblasts (CAFs) are important stromal cells in the tumor microenvironment of lung adenocarcinoma (LUAD). This review discusses the different cellular sources of CAFs and the main signaling pathways i...

Glioblastoma (GBM) is the most common and aggressive type of central nervous system cancer, characterized by high rates of recurrence and mortality. As the highest-grade glioma, patient prognosis remains poor despite mul...

Developing effective drugs for Alzheimer’s Disease (AD) is critically limited by insufficient brain exposure. To address this, structural optimization was employed to balance physicochemical properties and enhance bloo...

HER2-low breast cancer, defined as immunohistochemistry (IHC) 1+ or 2+ with negative in situ hybridization (ISH), has emerged as a clinically relevant therapeutic subgroup. We report the case of a 40-year-old woman with ...

Colitis-associated colorectal cancer (CAC) represents the most severe malignant complication of inflammatory bowel disease (IBD), characterized by high invasiveness, frequent recurrence, and poor prognosis. Recent studie...

Human induced pluripotent stem cells (iPSCs) are transforming adoptive cell therapy by combining unlimited self-renewal, broad differentiation potential, and high amenability to genome engineering. These attributes make ...

Mucinous cancers are characterized by tumor gland cells secreting copious amounts of mucus that forms gel-like structures. Pseudomyxoma peritonei (PMP), a rare yet prototypical mucinous malignancy, exemplifies this patho...

BackgroundBockenheimer disease is a rare subtype of venous malformations that involves all tissue planes of an upper extremity. This condition progresses throughout life and may cause pain, swelling, hematologic complica...

The rising concern of antimicrobial resistance, coupled with the continually challenging management of complicated diseases such as cancer, has provided momentum toward precision molecular medicine. This review provides ...

Small cell lung cancer (SCLC) remains one of the most aggressive malignancies, characterized by rapid proliferation, early metastatic dissemination, and poor long-term survival despite initial sensitivity to therapy. SCL...

Immunosuppression from human immunodeficiency virus (HIV) or other comorbidities increases susceptibility to gastrointestinal infections such as Entamoeba histolytica and cytomegalovirus (CMV). Although each pathogen can...

BackgroundPrimary diffuse leptomeningeal melanocytosis (PDLM) is a rare central nervous system neoplasm. Diagnosis is challenging in amelanotic variants because they lack the characteristic T1 hyperintensity on magnetic ...

LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency belonging to the spectrum of common variable immunodeficiency disorders, frequently associated with immune dysregulation, autoimmun...

BackgroundHydrops fetalis encompasses diverse fetal disorders with high perinatal mortality, and contemporary regional data are limited.MethodsWe conducted a single-center retrospective cohort study at a Saudi tertiary r...