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Abstract State-supported research funding agencies are critical to the scientific enterprise. However, it remains unclear how funding agencies cooperate with academic communities to realize common scientific goals. Here,...

Abstract Human herpesviruses exhibit diverse pathogenic outcomes and the molecular reasons are not fully understood. Human herpesvirus 6B (HHV-6B) causes exanthema subitum and encephalitis, whereas the closely related HH...

Abstract The nematode Ditylenchus destructor comprises multiple haplotypes with distinct host preferences, while the genetic basis remains unclear. We generate three genomes (Haplotypes A, B, and C) using hybrid assembly...

Abstract Klebsiella oxytoca is an under-recognised opportunistic pathogen increasingly associated with severe antimicrobial-resistant infections. Here, we report the first carbapenemase-producing K. oxytoca (CPKO) isolat...

Abstract Mitochondrial genomes of some animals remained almost unchanged architecturally for over half a billion of years, while other lineages exhibit conspecific variability. The drivers underlying this disparity remai...

Abstract Zoonoses are among the greatest threats to human health, with many zoonotic pathogens believed to have emerged following the Neolithic transition. Palaeomicrobiological investigations of the zooarchaeological re...

Abstract Genetic interaction and protein-protein interaction networks have proved among the most important tools for inference of gene function and genotype-phenotype relationship. It remains unclear, however, how these ...

Abstract The natural occurrence of 2,6-diaminopurine (Z) as a substitute for adenine (A) in certain bacteriophage genomes has profound evolutionary implications and promising biotechnological potential. Progress in this ...