NODOVOX | Discovery

Kynurenine promotes angiogenesis through mTOR signaling in head and neck squamous cell carcinoma

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Kynurenine promotes angiogenesis through mTOR signaling in head and neck squamous cell carcinoma

Shuoqi Lin et al · Nature Portfolio · 2026 · ISSN 2045-2322

Abstract Angiogenesis and its maturation play a crucial role in the progression and prognosis of head and neck squamous cell carcinoma (HNSCC). Tumor growth relies on an adequate blood supply to meet metabolic demands, w...

LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng

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Integrating transcriptomic data and artificial intelligence to personalize curative treatments for head and neck cancer patients

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Integrating transcriptomic data and artificial intelligence to personalize curative treatments for head and neck cancer patients

Stefano Cavalieri et al · Nature Portfolio · 2026 · ISSN 2397-768X

Abstract Personalized treatment in head and neck cancer remains limited despite substantial biological heterogeneity. Using the SuPerTreat project as a case study, we outline a prototype clinical decision support system ...

LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng

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Multimodal framework for the joint analysis of single-cell RNA and T cell receptor sequencing data predicts T cell response to cancer immunotherapy

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Multimodal framework for the joint analysis of single-cell RNA and T cell receptor sequencing data predicts T cell response to cancer immunotherapy

Chujun He et al · Nature Portfolio · 2026 · ISSN 2041-1723

Abstract T cell states are prognostic in different cancer types. Recent technologies enable joint profiling of T cell RNA and T cell receptor (TCR) sequences at single-cell resolution. Here we present the TCR-RNA Integra...

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Risk factors for postextubation pneumonia using diagnosis procedure combination and claims data in Japan

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Risk factors for postextubation pneumonia using diagnosis procedure combination and claims data in Japan

Junko Hirayama et al · Nature Portfolio · 2026 · ISSN 2045-2322

Abstract Intubation-related pneumonia negatively affects patient outcomes. Aspiration pneumonia occurring after extubation due to swallowing dysfunction, conceptualized as postextubation pneumonia (PEP), remains underrec...

LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng

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ALYREF-mediated RNA 5-methylcytosine modification promotes laryngeal cancer progression via stabilizing DDX11 mRNA

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ALYREF-mediated RNA 5-methylcytosine modification promotes laryngeal cancer progression via stabilizing DDX11 mRNA

Shanyan Bian et al · Nature Portfolio · 2026 · ISSN 2045-2322

Abstract Laryngeal cancer (LC) is one of the malignant tumors affecting the head and neck region. 5-methylcytosine (m5C) is a common RNA modification that contributes to the carcinogenesis process. Aly/REF export factor ...

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