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A Comparative Study Between Lipid A Extracted from Salmonella typhi and Pseudomonas Aeruginosa to Demonstrate the Extent of its Stimulation of Immune System

ISSN: 1812125X · Editor / fuente: University of Mosul, College of Education for Pure Science

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Cardiac Complexity Predicts Increased Immune Diagnostic Burden in 22q11.2 Deletion Syndrome
Artículo
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Cardiac Complexity Predicts Increased Immune Diagnostic Burden in 22q11.2 Deletion Syndrome
Jasmyn Atalla et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Background22q11.2 deletion syndrome (DS) is the second most common cause of congenital heart disease (CHD) and a multisystem disorder that contributes to substantial overall disease burden. Additionally, 22q11.2DS is the...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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A Novel Immunomodulatory Strategy to Control Multiple Immune Dysregulation Disorders in a Pediatric Patient
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A Novel Immunomodulatory Strategy to Control Multiple Immune Dysregulation Disorders in a Pediatric Patient
Jennifer D. Blackwood et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Immune dysregulation can lead to autoimmunity and autoinflammation. The goal of treatment is to balance targeted therapies while avoiding infections or other side effects, which becomes complicated with multiple diagnose...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Diagnostic Utility of Genetic Testing in a Complex Multisystem Presentation: A Case of CTLA4 Haploinsufficiency
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Diagnostic Utility of Genetic Testing in a Complex Multisystem Presentation: A Case of CTLA4 Haploinsufficiency
Priyanga Selvakumar et al · Rockefeller University Press · 2026 · ISSN 3065-8993
CTLA4 haploinsufficiency is caused by mutations in the CTLA4 gene. The loss of this important immune checkpoint leads to uncontrolled production of lymphocytes, causing infiltration of T cells into multiple organs (gastr...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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GATA2 Deficiency Presenting with Severe Immune Dysregulation
Artículo
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GATA2 Deficiency Presenting with Severe Immune Dysregulation
Aria Bruton Joe et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundGATA2 deficiency results from heterozygous pathogenic variants in the GATA2 gene, which encodes a zinc-finger transcription factor essential for hematopoietic stem and progenitor cell development. It is a highl...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Determining the Risk of Developing Severe Sepsis Using Genetic Profiling of Innate Immunity Genes
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Determining the Risk of Developing Severe Sepsis Using Genetic Profiling of Innate Immunity Genes
E.A. Polyakova et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Background and AimsThe immune response to an infectious agent is regulated by a complex network of signaling pathways involving numerous genes encoding inflammatory mediators, proteins of the innate and adaptive immune s...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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HEM-1-Associated Inborn Error of Immunity: A Case Series
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HEM-1-Associated Inborn Error of Immunity: A Case Series
Sebastian Chamorro Ordonez et al · Rockefeller University Press · 2026 · ISSN 3065-8993
NCKAP1L encodes hematopoietic protein-1 (HEM1), a component of the WASp family verproline-homologous protein (WAVE) actin regulatory complex, activated downstream of multiple immune receptors. HEM1 deficiency disrupts WA...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Heterogeneous CD21low B Cell Subsets and Their Functional Impact in Common Variable Immunodeficiency
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Heterogeneous CD21low B Cell Subsets and Their Functional Impact in Common Variable Immunodeficiency
Jitka Smetanová et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Atypical CD21low B lymphocytes are a naturally occurring transient subset that has been increasingly recognized in chronic diseases, such as infections and immune dysregulation, where they may persist for long. Their fat...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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A Biallelic HELIOS Nonsense Mutation Disrupting Dimerization Is Associated with a Novel Syndromic Immunodeficiency
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A Biallelic HELIOS Nonsense Mutation Disrupting Dimerization Is Associated with a Novel Syndromic Immunodeficiency
Hye Sun Kuehn et al · Rockefeller University Press · 2026 · ISSN 3065-8993
HELIOS is an IKAROS-family zinc-finger transcription factor that plays an important role in regulatory T cell function and conventional T cell homoeostasis. HELIOS shares a conserved N-terminal DNA-binding and C-terminal...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Investigation Into the Viscosity of Commercial IG Preparations
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Investigation Into the Viscosity of Commercial IG Preparations
Suzanne Strasters et al · Rockefeller University Press · 2026 · ISSN 3065-8993
All intravenous immunoglobulin (IVIG) products carry a boxed warning for the risks of renal dysfunction and thromboembolic events (TEEs). Patient-related thrombotic risk factors include hyperviscosity, a condition in whi...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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NFKB1 Truncating Variants Associated with Significant Autoimmunity and Lymphoproliferation in Common Variable Immunodeficiency
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NFKB1 Truncating Variants Associated with Significant Autoimmunity and Lymphoproliferation in Common Variable Immunodeficiency
Chi Ma et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Heterozygous NFKB1 variants have been increasingly identified in patients with common variable immunodeficiency. These patients, however, often experience substantial immune dysregulation beyond humoral deficiency. NFKB1...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Overlap in Immunologic Pathways Between Asthma and Primary Immunodeficiency Disorders
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Overlap in Immunologic Pathways Between Asthma and Primary Immunodeficiency Disorders
Jooyoung Moon · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundAsthma is traditionally conceptualized as a T helper 2 (Th2)-mediated inflammatory airway disease. However, increasing evidence suggests that primary immune dysregulation may underlie or phenotypically mimic as...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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The Hao-Fountain Syndrome Gene USP7 Restricts Neurotropic Orthoflavivirus Entry via Intrinsic Antiviral Activity
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The Hao-Fountain Syndrome Gene USP7 Restricts Neurotropic Orthoflavivirus Entry via Intrinsic Antiviral Activity
Boris Bonaventure et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Inborn errors of immunity (IEI) can manifest with neurological disorders, indicating genetic overlap between immune and nervous system diseases. However, neurological disorder genes are rarely screened systematically for...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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