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Abstract This study investigates the synthesis and evaluation of glycine-conjugated 5.0G polypropyleneimine dendrimers as an advanced nanocarrier system for the selective delivery of chloroquine. 5.0G PPI dendrimers were...

Abstract Among the epidermal growth factor receptor tyrosine kinases (EGFR) family, HER3 (Human epidermal growth factor receptor3) stands apart due to its minimal inherent intracellular kinase function. Its kinase domain...

Abstract The advancement of sustained-release drug delivery systems is profoundly reshaping the medicinal applications. This study highlights a novel approach to developing sustained-release esterase responsive drug deli...

Abstract Curcumin, a natural polyphenol with multifaceted anticancer properties, faces significant clinical translation challenges due to poor solubility, rapid metabolism, and low bioavailability. Hydrogels, as biocompa...

Intracellular levels of cyclic nucleotide second messengers are regulated predominantly by a large superfamily of phosphodiesterases (PDEs). Most of the different PDE variants play specific physiological functions; in fa...

Abstract Subarachnoid hemorrhage (SAH) is an extremely lethal cerebrovascular emergency that can lead to severe long term neurological deficits. Modern research evidence indicates that the incidence of SAH varies signifi...

Membrane transporters play a central role in protecting the body from xenobiotics (either by preventing their absorption, limiting their distribution, or promoting their elimination). Transporters can also participate in...