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BackgroundHeart failure (HF) with chronic arrhythmias is associated with autonomic dysfunction and poor outcomes. Heart rate variability (HRV) reflects autonomic dysfunction and predicts outcomes in HF. This study invest...

OBJECTIVES: Sudden cardiac death (SCD) is common in patients with end-stage renal disease receiving hemodialysis. SCD may be caused by electrolyte imbalance or malignant arrhythmias in hemodialysis patients. We aimed to ...

Abstract Multifocal Ectopic Purkinje-related Premature Contractions (MEPPC) syndrome is a recently recognized rare channelopathy caused by gain-of-function mutations in the SCN5A gene, leading to a high burden of prematu...

ABSTRACT Background Daily variability of heart rate in 24‐h Holter recordings in dogs with atrial fibrillation (AF) receiving antiarrhythmic drugs (AAD) is unknown and could influence medical decisions. Hypothesis/Obje...

Abstract Background Reliable ECGs are crucial for diagnosing arrhythmias, yet a lack of standardization impedes arrhythmia diagnosis and treatment in horses. Objectives To objectively determine an optimal position of Ein...

Drug-induced cardiac arrhythmias are central to physiology and pharmacology education, yet students often struggle to connect electrophysiological mechanisms with dynamic electrocardiographic (ECG) changes. We developed ...

Abstract Background Myocardial sleeves of the caudal vena cava are the predilection site for atrial tachycardia (AT) in horses. Caudal vena cava isolation guided by the ablation index, a lesion quality marker incorporati...

Abstract BackgroundAtrial fibrillation (AF) and atrial flutter (AFL) are common arrhythmias associated with the risk of ischemic stroke, which can be reduced with anticoagulation therapy. Thus, early diagnosi...

Abstract Background The protozoal parasite Trypanosoma cruzi causes myocarditis in dogs. Objectives To describe the cardiac diagnostic test results and outcomes of dogs naturally infected with T. cruzi. Animals Forty‐f...

Carbamazapine is a commonly used antiepileptic agent. Neurological abnormalities which can progress to coma, arrhythmias, respiratory depression and eye abnormalities such as nystagmus are seen in an intoxication setting...

We show that TANGO2 in mammalian cells localizes predominantly to mitochondria and partially at mitochondria sites juxtaposed to lipid droplets (LDs) and the endoplasmic reticulum. HepG2 cells and fibroblasts of patients...

Background: Wearable electrocardiography (ECG) devices such as smartwatches offer a novel means for detecting cardiac arrhythmias, particularly atrial fibrillation (AF), and ST-segment abnormalities. Their role in comple...

Abstract Background Cardiac disease is an important cause of morbidity and mortality in Irish Wolfhounds (IWs), but its prevalence and clinical characteristics in North American IWs are incompletely described. Hypothesis...

Abstract Background Ischemic stroke (IS) remains a leading cause of death and disability worldwide. Stroke–heart syndrome, triggered by acute cerebral ischemia, causes autonomic dysfunction that can result in myocardia...

OBJECTIVE: Patients with chronic kidney disease (CKD) have increased risk for cardiac arrhythmias. Other than comorbidities like diabetes mellitus and cardiovascular disease, factors like acidosis, uremia and electrolyte...

Objective: to evaluate the prevalence of cardiac problems, including myocardial iron deposition, pericarditis, and valvular abnormalities, among people with β-thalassemia and to shed light on the distribution of β-thal...

The occurrence of late potentials in dogs under doxorubicin-induced cardiomyopathy and their relationship with the development of ventricular arrhythmias or sudden death were studied. Seven adult mongrel dogs of both sex...

Abstract Left atrial appendage (LAA) aneurysm is a rare structural abnormality that can predispose to significant complications, including systemic embolism and complex supraventricular arrhythmias. Here, we report a 44-...

Left ventricular hypertrophy (LVH) is an enlargement of the left ventricle caused by chronically increased hemodynamic load, such as arterial hypertension or aortic stenosis. In the initial stages, LVH has a protective n...

Background. Long QT Syndrome (LQTS) is a hereditary cardiac channelopathy that predisposes individuals to malignant arrhythmias and sudden cardiac death. In athletes, physiological cardiac adaptations can mask or mimic L...

Abstract Trypanosoma cruzi infection in dogs can cause heart failure and sudden death with few treatment options available. A litter of 4 dogs living in a T cruzi endemic area were randomized to prophylaxis and nonprophy...

Abstract Background Distal renal tubular acidosis (dRTA) is an uncommon renal tubular disorder marked by impaired distal nephron acid excretion, resulting in hyperchloremic metabolic acidosis, persistent alkaline urine, ...

Background: Drug-resistant tuberculosis (DR-TB) is a major public health challenge in Sub-Saharan Africa (SSA), worsened by high HIV prevalence and limited healthcare infrastructure. Bedaquiline, a cornerstone DR-TB trea...