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The aim of the present study was to develop and evaluate chronomodulated rupturable pulsatile drug delivery of theophylline for the treatment of nocturnal asthma. Core tablets containing theophylline were coated with t...

Nimesulide was formulated as novel dual coated microparticles using chitosan (CTN) and ethyl cellulose (EC) as encapsulating materials for its improved delivery to the intestine and to prevent gastric irritation and incr...

The aim of the present study was to investigate the effects of drug solubility, inert pellet size and binders used in drug loading on release behavior from Eudragit NE-30 coated pellets. Aqueous solutions of highly wat...

Neste trabalho propusemos o desenvolvimento de filmes isolados constituídos de etilcelulose contendo novo aditivo de formulação, o alfa-glucoligossacarídeo (α-GOS), além do tensoativo Tween® 80, sendo este materia...

No presente trabalho foram desenvolvidas e avaliadas cinco formulações de péletes, contendo L-alanil-L-glutamina (glutamina dipeptídeo), em diferentes concentrações: F1 (9,07%); F2 (17,70%); F3 (27,98%); F4 (37,7...

Crohn's disease occurs at any part of gastro-intestinal tract (GIT) but the most susceptible is the ileo-cecal region. For an effective treatment of this disease is essential the drug to be released at ileo-cecal regio...