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BackgroundNitric oxide (NO) is a signalling and physiologically active molecule in animals, plants and bacteria. The specificity of the molecular mechanism(s) involved in transducing the NO signal within and between cell...

Copper is an essential trace element in the human body, extensively involved in key physiological and biochemical processes such as antioxidant defense, energy metabolism, neural signaling, and immune regulation. In rece...

Tianqing Zhang,1 Sijie Xiao,2 Yanfu Xia,3 Kun Chen,1 Honglan Liu,1 Ping Zhang,1 Li Luo1 1Department of Cardiology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of ...

Seed germination is severely constrained by soil salinity, limiting crop establishment in salt-affected agricultural lands. This study investigated whether seed priming with molybdenum nanoparticles (Mo NPs) enhances ger...

Abstract Background Variants in OTUD5 are associated with neurodevelopmental disorders (NDDs), yet the underlying molecular mechanisms remain unclear. This study aimed to investigate the pathogenicity of a novel OTUD5 va...

Abstract Background Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. Objectives To evaluate circulating concentrations of whole parathormone ...

Abstract Oocyte development requires tight regulation of transcription and RNA metabolism, which is coordinated by RNA-binding proteins, whose roles in mammalian oogenesis remain incompletely understood. Here, we identif...

Oxidative stress–induced cellular injury is a key mechanism underlying tissue dysfunction, and food-derived phenolic compounds have attracted interest as natural modulators of redox homeostasis. Sensory cells, includin...

Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeos...

Abstract Background Lung squamous cell carcinoma (LUSC) is one of the common pathological subtypes of non-small cell lung cancer, which poses significant treatment challenges due to poor response to conventional therapie...

Osteoporosis is a very common disease nowadays, and it is mostly seen in postmenopausal women. In postmenopausal women, with the decrease of estrogen, directly or indirectly, it makes the decrease of bone mineral density...

Asymptomatic malaria infections may affect red blood cell (RBC) homeostasis. Reports indicate a role for chronic hemolysis and splenomegaly, however, the underlying processes are incompletely understood. New hematology a...

OBJECTIVE: We aimed to evaluate thiol/disulfide homeostasis as an oxidative stress parameter in end-stage renal disease patients receiving different substitutive therapies. MATERIAL and METHODS: Twenty-four renal tran...

The targeted-modified low-molecular-weight pectin (LMP), a natural polysaccharide derived from citrus fruits, represents a promising food-derived immunomodulatory agent. This study assessed the efficacy of targeted-modif...

OBJECTIVE: The aim of this study was to determine a novel oxidative stress marker, plasma thioldisulphide homoeostasis, in patients with autosomal dominant polycystic kidney disease (APKD). MATERIAL and METHODS: Thirt...

Abstract Proper regulation of ribosome biogenesis is essential for stem cell function and tissue homeostasis, yet its upstream control in adult intestinal stem cells (ISCs) remains unclear. Here, we identify the WD repea...

In aquaculture nutrition, alternative protein sources, such as those derived from bacteria, have recently garnered significant attention as safe and viable replacements for traditional protein sources, including fish mea...

Phytoestrogens (PE) such as genistein (Gen) are considered a natural therapy to counteract the risk of cardiovascular diseases in postmenopausal women. Atherosclerosis is a chronic inflammatory process that, in the later...

"The spread of fake news has become a major problem for societies. Recent studies showed that when people are confronted with invented news, can believe and even generate a false memory of these events, and this is incre...

Huangjing (Polygonati Rhizoma) is an important medicinal and edible herb, which can be taken orally, brewed in tea, steeped in wine, or used in food processing.The fibrous roots of Polygonum cyrtonema, usually discarded ...

Background: Osteoporosis has long been considered a disorder confined to bone tissue. Growing evidence now highlights its systemic origins, governed by intricate communication between multiple organs. The multi-organ-bon...

Salt stress limits plant production in arid and semi-arid zones. Although Na2SO4 is frequent in saline soils, most studies on plant physiological responses to salt stress were conducted using NaCl. This study aimed to de...

Abstract Background High-oleic diets (HODs), have been proposed to improve lipid and glucose metabolism, yet clinical evidence remains inconsistent. This systematic review and meta-analysis aimed to quantitatively evalua...