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A simple and sensitive HPLC method was validated for assessment of in vitro and in vivo recovery of gatifloxacin using microdialysis. The validation parameters of linearity, precision, accuracy and limit of detection wer...

A simple and rapid SPE-HPLC-DAD method was developed for the determination of 5-fluorouracil (5-FU) in surface samples. A C18 column (250 x 4.6 mm i.d., 5 µm) and a similar pre-column were used for the separation at 25...

Alpinia officinarum has been used by long time in the traditional medicine and several commercial extracts containing it are available on the market. In this paper a reversed phase high performance liquid chromatography-...

A high performance liquid chromatography photo diode array UV detection electrospray ionization tandem mass spectrometry (HPLC-PDA-ESI/MSn) method was developed and validated for the quality evaluation of gamboge (dryed ...

A simple, specific, sensitive and validated RP-HPLC method for the simultaneous estimation of amlodipine (AMB) and valsartan (VAL) in marketed tablet formulation was developed. The analysis was carried out on a phenomene...

A reverse phase high-performance liquid chromatography-photodiode array detector (RP HPLC-DAD) method for simultaneous determination of lamivudine (3TC), zidovudine (AZT), two nucleoside reverse transcriptase inhibitors,...

A simple reversed phase HPLC method was developed for simultaneous estimation of pioglitazone, glibenclamide, and glibenclamide impurities A and B from a combination drug product. The drugs and impurities are well separa...

A sensitive and specific high performance reversed phase liquid chromatographic method was developed for quantification of citicoline monosodium (CTM) in human plasma. The active drug was isocratically eluted at a flow r...

In the present study, a simple, rapid and precise liquid chromatographic method was developed and validated for the determination of ezetimibe in its dosage form. Ezetimibe was separated in a 100 x 4.6 mm i.d., C18 colum...

To develop a high performance liquid chromatography method for the simultaneous determination of cortisone and cortisol in rat serum and apply it for pharmacokinetics. After addition of pirfenidone as internal standard (...

A simple HPLC method was developed to study the pharmacokinetics of tobramycin in rat after intravenous administration. The plasma samples were deproteinized with acetonitrile after addition of the internal standard, net...

Gastric ulcer is one of ulcerous diseases and may result in some changes of many enzymes and transporters concerned with metabolism and disposal of drug. The pharmacokinetic of drug should be different between peptic ulc...

The objective of carrying out this research work was to investigate the effect of chirality on stereospecific dissolution of omeprazole enantiomers from various marketed racemic omeprazole products. Omeprazole is used fo...

HPLC-DAD was used and validated for the simultaneous determination of five flavonoids (rutin, quercitrin, quercetin, kaempferol and isorahamnetin) in rabbit plasma. Chromatographic separation was performed on an Aglient ...

A new sensitive, rapid and simple HPLC-DAD method has been developed and validated for simultaneous determination of captopril (CAP), hydrochlorothiazide (HCTZ) and their related compounds, captopril disulfide (CAD), chl...

Semen Persicae was a traditional Chinese medicine for the treatment of diseases such as inflammation and hyperlipemia. Amygdalin was one of the main active ingredients of this traditional Chinese medicine. In this paper,...

A fast and simple HPLC-PDA method for rosmarinic acid quantification in Rosemary leaves powder was validated. The analyses were performed using a C18 column in isocratic conditions and detection at 254 nm. Performing the...

An ultraviolet (UV) spectrophotometric method was developed for the analysis of telithromycin, member of the ketolides, in drug substance and coated tablets. The method validation yielded good results, such as the range,...

A bioanalytical micromethod was described for the quantification of amphotericin B in plasma by HPLC. The method showed high absolute recovery, good linearity (0.1-10.0 μg/mL, r2 = 0.999), sensitivity (limits of quantif...

Rhizoma Paridis saponins (RPS) were considered to be the principal bioactive components of Paris polyphylla Smith var. yunnanensis. Intestinal microflora-mediated metabolism may affect their pharmacological activities in...

A sensitive and accurate HPLC-UV method for the quantification of fluconazole (FNZ) in human plasma has been developed. The sample was prepared by liquid–liquid extraction (LLE) of FNZ from plasma using ethyl acetate. ...

A reversed-phase high-performance liquid chromatographic (RP-HPLC) method for related substances test of seratrodast in bulk drugs has been developed. The separation was achieved on a ZirChrom Kromasil C18 (200 mm×4.6...

Choline citrate (CC) and acetylmethionine (AM) are lipotropic drugs used in several pharmaceutical formulations. The objective of this research was to develop and validate a high performance liquid chromatographic (HPLC...

The aim of the study was to characterize the preclinical pharmacokinetics and comparative pharmacokinetics of pure vitexin-2"-O-rhamnoside (VR) in mice after oral and intravenous administration at dose of 30 mg/kg. A sen...