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Abstract Laryngeal cancer (LC) is one of the malignant tumors affecting the head and neck region. 5-methylcytosine (m5C) is a common RNA modification that contributes to the carcinogenesis process. Aly/REF export factor ...

Abstract Background Covalent protein modification by drugs or their reactive metabolites has emerged as an important mechanism underlying pharmacological activity. However, its contribution to the therapeutic effects of ...

Abstract Background Neuroinflammation following intracerebral hemorrhage (ICH) is a critical contributor to secondary brain injury. Lactylation modification, a novel epigenetic regulatory mechanism, may participate in pa...

Abstract Background Poly (ADP-ribose) polymerase inhibitors (PARPis) are the standard of care for primary ovarian cancer (OC), yet adverse events (AEs) frequently necessitate dose modifications. The prognostic impact of ...

Objective: Periodontitis is a chronic inflammatory disease that severely affects oral and general health. N7-methylguanosine (m7G) methylation plays critical roles in regulating gene expression and cellular functions. Me...

Abstract Background Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma. Fatty acid synthase (FASN) is a key lipogenic enzyme implicated in tumor progression, but its regulation in DLBC...

Abstract Histone modifications and chromatin‐binding proteins play crucial roles in regulating gene expression in eukaryotes, with significant implications for fungal pathogenicity and development. However, profiling t...

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) stands as the most widespread chronic liver disorder globally. Histone β-hydroxybutyrylation (Kbhb)—a novel post-translational modif...

ObjectiveSuperfine cement-based grouting materials generally suffer from limitations including high bleeding rates, unfavourable rheological properties, poor stability, and strength retrogression. These issues can be mit...

Objectives Promoting regular physical activity (PA) is essential in cardiac rehabilitation; yet many patients exhibit low levels of PA. In January 2022, the Improving Physical Activity (IMPACT) trial, a randomised contro...

Prenatal exposure to fine particulate matter (PM2.5) has been associated to childhood atopic dermatitis (AD), but the critical exposure window and the role of maternal inflammatory pathways remain unclear. We analyzed 40...

Abstract The massive production of plastics, together with inadequate waste management, has intensified the problem of plastic pollution. Recently, the scientific community has increasingly investigated the interactions ...

Background Inadequate dietary diversity during complementary feeding contributes to high childhood malnutrition rates in sub-Saharan Africa. Understanding relationships between dietary quality and nutritional outcomes ac...

Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...

Objectives Smoking is recognised as one of the strongest environmental risk factors for the development of rheumatoid arthritis (RA). Cigarette smoke increases protein post-translational modifications (PTMs), including c...

Recycling of construction waste is essential for sustainable cement-based materials, yet the variable composition of recycled autoclaved aerated concrete (AAC) powder pose significant challenges when used in grouting app...

This paper examines modifications of verse numbering that were made to the Lutheran translation of the Book of Revelation (or Revelation of John, New Testament, Edition 1545) in two important revision Editions of the 17t...

Tesis Energía y Ambiente (maestría) - Instituto Tecnológico de Buenos Aires, Buenos Aires - Karlsruher Institut für Technologie, Karlsruhe, 2024 "In the global effort to reduce greenhouse gas emissions and enhance en...

Background and aims Meat-borne Staphylococcus aureus (S. aureus) remains a leading global foodborne pathogen harbouring novel enterotoxin genes (NEGs) encoding superantigenic toxins with conditionally enhanced pathogenic...

Learners face numerous hurdles while acquiring a second language. The use of mobile applications and digital technologies in language learning enhances the language proficiency of the learners. The objective of the study...

Food texture is increasingly recognized as a determinant of nutritional safety, metabolic regulation, and overall health. However, conventional approaches to texture modification rely primarily on hydrocolloids, mechanic...

ABSTRACT Background The genome‐wide profiling of chromatin states that are defined by different histone posttranslational modifications, known as epigenomic profiling, is crucial for understanding the epigenetic regula...

Abstract Metastasis is the leading cause of cancer-related deaths. Understanding the molecular mechanism of tumor metastasis is of great significance to cancer research. However, the molecular diagnosis and treatment of ...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...