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The upcoming A+ era of the LIGO–Virgo–KAGRA network—featuring upgrades to Advanced LIGO (aLIGO+) and Advanced Virgo (AdV+)—will enable more frequent and precise observations of binary neutron star (BNS) mergers, ...

Secure attachment of repair constructs to native cartilage and underlying bone tissues remains a major unmet need in chondral and osteochondral surgery. Currently existing injectable or scaffold-based cell carriers, whil...

Abstract In order to address health monitoring issues on offshore wind turbines, while taking into account engineering know-how and constraints, we propose a robust model identification procedure based on reliability of ...

Objectives Promoting regular physical activity (PA) is essential in cardiac rehabilitation; yet many patients exhibit low levels of PA. In January 2022, the Improving Physical Activity (IMPACT) trial, a randomised contro...

China is the world's largest emitter of CO2 and aims to reach carbon neutrality by 2060. However, China's terrestrial ecosystem carbon budget (CB), which is crucial to accelerating the realization of the Paris Agreement ...

Coral reefs are among the most diverse and productive ecosystems on the planet, providing goods and services to millions of people. Yet, they are threatened by a combination of natural and anthropogenic disturbances, whi...

Abstract Introduction Bone and joint infections (BJIs) are complex and difficult to eradicate, and have high relapse rates and limited oral treatment options. Tetracyclines combine favorable bone penetration, oral bioava...

Materias / palabras clave: breast cancer; cancer-related; dermatoses; histiocytoses; systemic disease; xanthogranuloma

Abstract This multicenter, first-in-human Phase 1 study (NCT04956640) evaluated olomorasib (LY3537982), a next-generation KRAS G12C inhibitor designed to enhance target occupancy at low absolute exposures. In total, data...

Abstract Background Objective structured clinical examinations (OSCEs) have recently been integrated as one of the academic assessment tools for French undergraduate medical students. Data are scarce regarding the correl...

Aims: Cementless femoral fixation is widely used in total hip arthroplasty (THA), with increasing interest in shorter femoral component designs. These femoral components aim to preserve proximal bone, promote physiologic...

Abstract Background Polypharmacy and pharmacokinetic alterations expose elderly patients to an increased risk of iatrogenic events, hospitalisation, and healthcare costs. Therapeutic optimisation is based on identifying ...

PurposeChildren today face increasing cognitive, emotional, and social demands that may undermine their well-being and development. This study evaluated the effects of a school-based intervention combining attentional pr...

IntroductionSweating is essential for thermoregulation during exercise but causes variable losses of water and sodium chloride (NaCl). Field-based methods to assess these losses are limited by sampling errors and the lac...

Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with limited predictive markers to guide personalized treatment, particularly in human papillomavirus (HPV)-negative cases, whic...