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Analysis of rat toxicology studies: statistical agreement between virtual and concurrent controls in detecting treatment effects on liver enzymes

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Analysis of rat toxicology studies: statistical agreement between virtual and concurrent controls in detecting treatment effects on liver enzymes

Guillemette Duchateau-Nguyen et al · Frontiers Media S.A · 2026 · ISSN 1663-9812

IntroductionVirtual control groups (VCGs) are proposed as a means to reduce reliance on live animals in preclinical toxicology studies. Despite the potential benefits of VCGs, concerns remain regarding their comparabilit...

LCC LCC:Therapeutics. PharmacologyIdioma eng

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SHP1 (PTPN6) Deficiency Defines a New PIRD with Infant-Onset Anemia and Severe Hyperinflammatory Lung Disease

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SHP1 (PTPN6) Deficiency Defines a New PIRD with Infant-Onset Anemia and Severe Hyperinflammatory Lung Disease

Farsh Moussavi-Harami et al · Rockefeller University Press · 2026 · ISSN 3065-8993

Primary immune regulatory disorder (PIRD) is a subset of inborn errors of immunity (IEIs) caused by disruption of genes involved in regulating the immune response. PIRDs are predominantly characterized by dysregulated im...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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