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Abstract Personalized treatment in head and neck cancer remains limited despite substantial biological heterogeneity. Using the SuPerTreat project as a case study, we outline a prototype clinical decision support system ...

Abstract Aims Patients with spastic cerebral palsy (CP) are at a high risk of neurogenic hip dysplasia/subluxation depending on the severity of the neuromuscular disorder. Untreated, approximately one third of all patien...

The Technology Readiness Level (TRL) has been adopted since 2014 within the European Union (EU) as a metric to evaluate the maturity of results from EU-funded research and innovation projects. This metric is crucial for ...

Introduction/Objectives: Sarcopenia, characterized by the progressive loss of muscle mass and strength, is highly prevalent in patients on peritoneal dialysis (PD), significantly affecting their quality of life (QoL). Th...

IntroductionSTING-associated vasculopathy with onset in infancy (SAVI) is a rare, severe type I interferonopathy caused by gain-of-function mutations in STING1, leading to early-onset systemic inflammation, cutaneous vas...

Beetles of the family Zopheridae (Coleoptera, Tenebrionoidea) are rarely reported from Bulgaria and available data on their distribution in the country are scarce. Here, we provide an updated checklist of the family, bas...

The present study aimed to investigate the effectiveness of recreational citizen science in biodiversity monitoring. The goal was to evaluate whether a minimal training protocol can maintain data quality while engaging l...

Introduction Tuberculosis (TB) remains a significant health burden in 25 low- and middle-income countries. Despite TB being more cost-effective to prevent and treat its funding is disproportionately lower than that of HI...

Abstract Background Cerebellar ataxia (CA) is a neurodegenerative disorder characterized by progressive impairments in coordination, balance, and gait disturbances. Conventional rehabilitation therapies offer only limite...

IntroductionNurses and nursing assistants working in high-intensity hospital settings are exposed to demanding workloads, organizational pressure, and substantial emotional strain, factors commonly associated with job di...

Abstract Background Children with Unilateral Cerebral Palsy (UCP) are characterized by significant upper limbs (ULs) impairment that hinders daily activities and participation, requiring accurate assessment. Although mot...

Abstract This study explores the use of an upper-limb wearable exoskeleton for teaching violin technique to novices through haptic-assisted training. The educational potential of this technology was evaluated using a fra...

Abstract Background Epidermolysis bullosa (EB) is a rare genetic disorder that causes extreme skin fragility, chronic pain, and functional impairment, with major psychosocial and economic consequences. Health-related qua...

IntroductionLung adenocarcinoma remains the most common subtype of non–small cell lung cancer (NSCLC), yet molecular epidemiology and real-world outcomes in Caribbean populations are poorly documented.MethodsWe conduct...

Abstract Introduction Respiratory syncytial virus (RSV) is the leading cause of respiratory infections and hospitalization among infants and a major burden on pediatric emergency department (EDs). Nirsevimab has recently...

Studies assessing marine physical stock accounts compliant with the globally adopted System of Environmental-Economic Accounting - Ecosystem Accounting are limited. These studies typically focus on ecosystems easy to map...

Genetic hemochromatosis (GH) and alpha-1 antitrypsin (AAT) deficiency (AATD)  are two autosomal recessive disorders associated with an increased risk for liver injury. Among different AATD and GH genotypes, the M-Malton...

Abstract Agricultural management is critical in shaping soil carbon (C) stocks, pools and fluxes. The soil priming effect (PE) is known as a key component of the global C cycle that reflects alterations in soil organic c...

B. infantis abundance in the infant gut may be associated with growth and health outcomes. However, these relationships have not been widely studied in settings where B. infantis is a dominant early-life commensal and gr...

Background: Chronic kidney disease (CKD) is a progressive condition characterized by structural and functional impairments in the kidneys, affecting around 10–15% of the global population. Kidney transplantation from l...

The growth of variable renewable energy sources has increased the occurrence of curtailment in power systems, particularly in regions affected by transmission constraints and limited operational flexibility. Reliable for...

ABSTRACT Background and Aims Patient and public involvement and engagement (PPIE) in research is crucial for producing knowledge that is meaningful to the participating community. Sharing PPIE principles into practical t...

Abstract Background Interventional management of chronic obstructive pulmonary disease of the emphysema phenotype, include uniportal, non-intubated, video-assisted thoracic surgery (UNI-VATS) lung volume reduction surger...