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Background Residents in difficulty represent a significant challenge in postgraduate medical education. Early, structured remediation may improve academic and clinical performance, yet regional evidence from family medic...

Este artigo resulta de uma pesquisa de mestrado desenvolvida entre 2020 e 2022 com a primeira turma da Licenciatura em Educação Escolar Quilombola, ofertada pela Universidade da Região de Joinville (Univille). O estud...

Understanding structure at the atomic scale is fundamental for understanding the functioning and the development of materials with improved properties. Compared with other probes providing atomic resolution, electrons of...

Autosomal-dominant hyper-IgE syndrome (AD-HIES) is characterized by chronic mucocutaneous candidiasis, recurrent sinopulmonary pneumonias, noninflammatory atopic dermatitis, extremely high levels of serum IgE, and non-im...

IntroductionInborn errors of immunity are genetic disorders that result in the absence or dysfunction of critical components of the immune system. Spondyloenchondrodysplasia (SPENCD) is one of these diseases, causing imm...

BackgroundPrimary atopic disorders (PADs) are monogenic inborn errors of immunity marked by severe allergic disease. Heterozygous gain-of-function (GOF) variants in STAT6 have recently been recognized as a PAD associated...

Abstract Objectives Gastroesophageal reflux disease (GERD) is estimated to affect up to one-quarter of the Italian population, generating immense treatment costs. An emergent surgical treatment involving implantation of ...

Abstract Introduction Glecaprevir/pibrentasvir (G/P) is globally approved for the treatment of chronic hepatitis C virus (HCV) infection and for acute HCV infection in the USA. The efficacy and safety of G/P has been cl...

Calibrated measurements of electron velocity distribution functions (VDFs) are necessary to characterize fluid and kinetic processes in weakly collisional and nearly collisionless plasmas such as the solar wind. Therefor...

Between 2005 January 1 and 2017 November 25, the Wind spacecraft measured 3,996,051 electron velocity distribution functions (VDFs) in the near-Earth solar wind. The instrument was calibrated, and velocity moments were ...

BackgroundSevere combined immunodeficiency (SCID) is a life-threatening condition that requires urgent medical attention. Newborn screening (NBS) using the T cell receptor excision circle (TREC) assay facilitates early d...

NCKAP1L encodes hematopoietic protein-1 (HEM1), a component of the WASp family verproline-homologous protein (WAVE) actin regulatory complex, activated downstream of multiple immune receptors. HEM1 deficiency disrupts WA...

IntroductionOSMR encodes oncostatin M receptor beta (OSMRβ), a cell surface receptor of the gp130 family that binds OSM and IL-31, and is highly expressed on fibroblasts. The gp130 family comprises signaling proteins, m...

We previously reported that inherited human retinoic acid-related orphan receptor gamma T (RORγT) deficiency underlies mycobacterial disease and chronic mucocutaneous candidiasis (CMC) in seven patients from three ances...

IntroductionInborn errors of interferon response factors (IRFs) are a subset of monogenic inborn errors of immunity, occurring as a result of damaging variants in the IRF genes. Of these diseases, IRF4 deficiencies are a...

MYB is a transcription factor and master regulator of hematopoiesis with a central role at multiple stages of B and T cell development. We identified ten heterozygous germline MYB variants in seven families and four unre...

In situ observations by Parker Solar Probe (PSP) suggest that the heliospheric current sheet (HCS) undergoes near-continuous magnetic reconnection close to the Sun, in stark contrast to scarce observations of this phenom...

Abstract Quantifying luminescence signal resetting of sand grains in turbid waters is essential for both sediment dating and tracing, yet direct measurement under natural subaqueous conditions remain scarce. Here, we pre...

As artificial intelligence (AI) becomes increasingly integrated into mental healthcare, it presents both opportunities to expand access and challenges related to ethics, safety, and regulation. This white paper examines ...

Abstract The effects of high‐load (HL) versus high‐volume (HV) resistance training (RT) on various molecular outcomes are similar. However, mitochondrial responses remain understudied. Therefore, the purpose of this ...

Trends over time in the protected area coverage of Key Biodiversity Areas is an indicator to track progress for global environmental targets, including Sustainable Development Goals 14 and 15, and Target 3 of the Kunming...

X-linked inhibitor of apoptosis (XIAP) is essential for innate and adaptive immune responses, including programmed cell death inhibition, NFkB and MAPK activation, NLRP3 inflammasome activity regulation, and TNFR signali...