Buscar recursos académicos

The development of anti-CD3 antibody-based T cell engager therapeutics has improved the treatment of various malignancies, yet the challenge of achieving tumor-specific targeting while minimizing on-target off-tumor effe...

Human induced pluripotent stem cells (iPSCs) are transforming adoptive cell therapy by combining unlimited self-renewal, broad differentiation potential, and high amenability to genome engineering. These attributes make ...

A method development aimed for high-throughput and automated antibody screening holds great potential for areas ranging from fundamental molecular interactions to the discovery of novel disease markers, therapeutic targe...

Jiahui Zhang,1– 3,* Junran Tong,1– 3,* Yang Sun,4,* Jinpeng Sun,1– 3 Ran Gao,1– 3 Di Sun,5 Xiaopeng Guo,6 Yumiao Wei1– 3 1Department of Cardiology, Union Hospital, Tongji Medical College...

Biologic therapeutics have transformed the treatment of chronic and life-threatening diseases, yet their clinical use depends almost entirely on parenteral administration. Oral delivery is the preferred route for patient...

Abstract Background The most investigated form of autoimmune-long-QT-syndrome (LQTS) is caused by circulating anti-Ro/SSA(Sjögren’s syndrome-related antigen-A)-52kD antibodies, which cross-react with a specific sequen...

Amyloids constitute a class of protein and protein fragments believed to be involved in the pathologies associated with Alzheimer’s, Parkinson’s and Creutzfeldt‐ Jakob diseases. These proteins can self‐assemble i...