Buscar recursos académicos

Atherosclerosis, driven by elevated cholesterol levels, remains a major risk factor for cardiovascular disease. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), the rate-limiting enzyme involved in cholesterol bio...

Abstract Humans are exposed to thousands of chemicals throughout their life. Many of these chemicals are detected in blood and have been catalogued in the Blood Exposome Database. Comprehensive hazard assessment of a che...

Abstract Generative deep learning models have demonstrated significant potential in designing drug-like molecules. However, medicinal chemistry typically requires generating analogues that combine structural similarity w...