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Several new 1,2,5-oxadiazole N-oxide derivatives and some deoxygenated analogues were synthesized to be tested as potential selective hypoxic cell cytotoxins. Compounds prepared were designed in order to gain insight int...

The Nagoya Protocol on Access and Beneft Sharing (ABS) was implemented to further develop the third objective of the Convention on Biological Diversity, the fair and equitable sharing of benefts arising out of the utiliz...

Background. Viral infections remain a major global health threat despite advances in vaccines and antiviral drugs due to the rapid emergence of resistance and new viral pathogens. Antiviral peptides (AVPs) are promising ...

Background Cognitive–behavioural theories of panic disorder posit that panic attacks arise from a positive feedback loop between arousal-related bodily sensations and perceived threat. In a recently developed computati...

The behavioral response of a parasitoid shows the effect on host parasitism patterns at a given host distribution. As a result, an increase or decrease in parasitism intensity according to local host densities is found. ...

Background: Forests are used for multiple purposes worldwide, which often include timber harvest, firewood extraction and livestock raising. An excessive pressure on multipurpose systems may decrease soil cover, promotin...

Mentha suaveolens subsp. timija is an aromatic herb with a spearmint flavor that plays an important role in the treatment of a wide range of diseases. It has various biological activities, including serving as a natural ...

"Bipartite graphs have received some attention in the study of social networks and of biological mutualistic systems. A generalization of a previous model is presented, that evolves the topology of the graph in order t...

ABSTRACT Background and Aim Antimicrobial resistance (AMR) has been a growing crisis of economic, clinical, and public health concern for years. Different mechanisms of why and how AMR develops have been suggested and st...

Abstract The growing threat of antibiotic-resistant bacteria calls for the urgent development of novel antimicrobial agents. Binary chalcogenide nanoparticles, particularly Ag2Se nanoparticles, have emerged as promising ...

Ilex paraguariensis Saint Hilaire (St. Hil) is an important crop in the north of Argentina, mainly cultivated in the Misiones province. Trichoderma genera are well known for their biological control and plant growth-prom...

Background and Aim: Ticks and tick-borne diseases (TBD) continue to pose a significant threat to livestock production and rural livelihoods in sub-Saharan Africa (SSA). The control of ticks has relied predominantly on th...

Background: Combining radiotherapy (RT) with immune checkpoint inhibitors (ICIs) offers potential synergy through RT-induced immunogenic cell death and enhanced systemic immunity. However, optimal RT dose, fractionation,...

Dermatomyositis (DM) is one of the so-called idiopathic inflammatory myopathies (IIM). Dermatomyositis is an autoimmune disorder characterized by the presence of cutaneous lesions and/or symptoms of muscle involvement wi...

Acute semistatic toxicity tests were carried out for 96 h with first zoeae and young crabs of Chasmagnathus granulata. Survival curves and LC50 (lethal concentration 50, the concentration which produces the death of 50% ...

Quinolines are well-established scaffolds in drug discovery and form the core of many FDA-approved medicines. Among their reduced analogues, hexahydroquinolines (HHQs) have gained increasing attention due to their struct...

Uncaria gambir Roxb (URG) is one of the plants from West Kalimantan predicted to contain antioxidant and anti-breast cancer. This study aims to test the antioxidant and anti-breast cancer potential. UGR leaves were extra...

Rapid establishment of herd immunity with vaccination is effective to combat emerging infectious diseases. Although the incorporation of adjuvant and intradermal (ID) injection could augment early responses to the vaccin...

Abstract Among various biological agents, bacteriocins are important candidates to control Listeria monocytogenes which is a foodborne pathogen. In this study, a novel bacteriocin, named agilicin C7, was isolated from Li...

Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the sacroiliac joints, spine, and peripheral joints. The widespread application of biological agents has led to significant clinical im...

Abstract Background Environmental studies often evaluate how exposures influence health outcomes through intermediate biological processes. In practice, researchers are often interested in complex exposure mixtures rathe...

Abstract Bacillus thuringiesis infects and kills insect larvae via its spores and associated entomotoxin-containing parasporal bodies (PSBs). We show that endospores and PSBs of B. thuringiensis Sv. Israëlensis are cove...