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Abstract Background Bone marrow-derived cell (BMDC) transplantation is increasingly recognized as a valuable strategy in regenerative therapies. However, the data regarding the impact of BMDC transplantation on the sever...

Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeos...

İn this study, renal transplant recipients who were complicated with tuberculosis, were analyzed with special reference to prevalence, outcome, therapy and drug toxicity. Among 520 patients, 22 (4.2%) were diagnosed to ...

OBJECTIVE: Cardiovascular diseases are the main reason of death in patients with renal transplantation (Rtx). Osteoprotegerin (OPG) is produced by osteoblasts and is linked to increased cardiovascular risk in Rtx. OPG ac...

SASH3 deficiency is an X-linked combined immunodeficiency characterized by recurrent sinopulmonary, cutaneous, and mucosal infections, refractory autoimmune cytopenia, and immune dysregulation. We report here the first t...

OBJECTIVE: The aim of our study was to determine the frequency and risk factors of osteoporosis in patients who had undergone renal transplantation in our clinic and had a functional graft. MATERIAL and METHODS: This s...

in this study patients with cytomegalovirus(CMV) disease among 548 renal transplant patients being followed up at our clinic during 1983-1998, were evaluated. Eight patients (%1.4) had active CMV disease. The average p...

Anemia is a frequent problem in renal transplant recipients, the most frequent cause being erythropoietin deficiency due to allograft failure. Parvovirus B19 can cause persistent viremia and erythropoietin resistant eryt...

Hoyeraal-Hreidarsson syndrome (HHS) represents the most severe form of dyskeratosis congenita (DC), a telomere biology disorder caused by pathogenic variants in genes involved in telomere maintenance. DKC1 encodes dysker...

CTLA4 haploinsufficiency is caused by mutations in the CTLA4 gene. The loss of this important immune checkpoint leads to uncontrolled production of lymphocytes, causing infiltration of T cells into multiple organs (gastr...

BackgroundRAS-associated autoimmune leukoproliferative disorder (RALD) is a rare immune-dysregulation syndrome caused by pathogenic mutations in RAS–MAPK pathway genes, most commonly KRAS. It is characterized by autoim...

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder caused by loss-of-function mutations in the FOXP3 gene, which is critical for the development of functional regulato...

BackgroundT cell–mediated hepatitis is an uncommon cause of acute pediatric liver injury. Most patients respond to steroids, but management of refractory disease remains challenging. We describe four patients with non-...

IntroductionToll-like receptor 8 gain-of-function (TLR8 GOF) is a recently described inborn error of immunity caused by activating mutations in Tlr8. Pathogenic variants lead to constitutive signaling in myeloid cells an...

Abstract Background Signaling molecules play a critical role in regulating stem cell-mediated bone regeneration. In this study, we investigated the effect of EphB4 gene transfection on the osteogenic differentiation and ...

We present the case of a 50-year-old man with a history of rheumatoid arthritis, chronic bronchitis, with a history of multiple lung infections, including Mycobacterium avium complex and Aspergillus terreus starting in h...

"El estudio y aplicación de la cirugía asistida por computadora ha crecido notablemente en los últimos diez años, de la mano del veloz incremento del poder de cómputo de procesadores a un costo accesible. A su vez, ...

Fil: Cardozo, Alejandra Johana. Hospital Italiano; Argentina. Como el sistema nervioso tiene una capacidad limitada de autorreparación, y la neurogénesis en el adulto está restringida a ciertas regiones del cerebro, ...