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Malignant solid tumors of the gastrointestinal tract are clinically rare in children, with malignant solid tumors of the esophagus being particularly uncommon. Clinical reports on esophageal cancer in children are extrem...

Weiya Zhuang,1 Daozhe Lin,2 Chengliang Chen2 1Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, People’s Republic of China; 2Department of Thyroid an...

BackgroundOmental infarction in pregnancy (OIP) is rare. Its symptoms, clinical signs, and imaging features are frequently non-specific, posing tremendous diagnostic challenges that are easy to overlook and may lead to s...

IntroductionBone-seeking radiopharmaceuticals are the treatment of choice with clinical benefits for patients with extensive skeletal metastases, but they can also cause serious radiation-related adverse events (rrAEs). ...

BackgroundLeft bundle branch block (LBBB) is a heart rate (HR)–dependent cardiac conduction disorder that may occur in the absence of structural heart disease and can be associated with painful episodes. Evidence suppo...

BackgroundCentral nervous system (CNS) relapse in acute lymphoblastic leukemia (ALL) may occur despite systemic remission and can present with isolated neuro-ophthalmologic symptoms. Early diagnosis may be challenging as...

Transitional cell carcinoma (TCC), or urothelial carcinoma, is the most common malignant tumor of the canine urinary bladder or urethra, often causing urinary obstruction. While chemotherapy is generally considered as pr...

BackgroundGranular cell astrocytoma (GCA) is a rare, morphologically distinct variant of IDH-wildtype glioblastoma that can appear deceptively low-grade yet behave aggressively. Its molecular features remain poorly defin...

BackgroundMutations in the PLA2G6 gene cause a spectrum of neurodegenerative disorders, with autosomal recessive early-onset Parkinson’s disease (AREP) and dystonia-parkinsonism (DP) representing the two primary subtyp...

Abstract Background Iodine plays a critical role in producing thyroid hormones essential for brain development. An imbalance of iodine, whether deficiency or excess, can disrupt thyroid function. Iodine-induced hypothyro...

Severe gingival inflammation, which is uncommon in pediatric patients, often indicates underlying systemic conditions. Leukemia, autoimmune diseases, and allergic symptoms can cause gingivitis owing to systemic inflammat...

Two adult domestic shorthair cats were evaluated for progressive neurologic deficits caused by spinal cord compression secondary to vertebral osteosarcoma, giant-cell subtype. Feline giant cell osteosarcoma represents a ...

Multiple Primary Cancers (MPCs), especially synchronous combined hepatocellular-cholangiocarcinoma (cHCC-CCA) complicated with gallbladder adenocarcinoma, are extremely rare clinically. This case report discusses a 73-ye...

BackgroundRare epidermal growth factor receptor (EGFR) mutations have a low incidence, and their response to EGFR tyrosine kinase inhibitors (TKI) has not been sufficiently studied. L747P is a rare EGFR mutation located ...

Abstract Background Appendiceal mucinous adenocarcinoma (AMA) is exceptionally rare, constituting less than 0.5% of all gastrointestinal malignancies and demonstrating an annual incidence of only 1 to 2 cases per million...

Background: Viscero-abdominal disproportion is a major limiting factor for primary abdominal wall closure in patients with giant omphalocele. The application of fascial traction has been shown to be an effective strategy...

Abstract Introduction and objectives Perindopril-induced thrombocytopenia is a rare but potentially serious adverse drug reaction. It remains underrecognized in clinical practice, particularly in elderly patients with ca...

BackgroundUlceration is a common complication of infantile hemangioma, and its management poses unique difficulties when the lesion is located in high-risk areas like the scrotum. This case report details the successful ...

The majority of patients with cholecystolithiasis are asymptomatic. Hemobilia is a rare complication of cholecystolithiasis. It is also an uncommon cause of upper gastrointestinal hemorrhage, where the source of bleeding...

Abstract Background Diffuse astrocytoma (DA) is the most common intraparenchymal brain tumor, primarily occurring in the frontal and temporal lobes. However, its occurrence in the lateral ventricles is rare. Case present...

BackgroundComplex anal fistulas remain a surgical challenge due to their intricate anatomy, high recurrence rates, and potential for sphincter injury. We report a rare case of complex anal fistula with multiple external ...

BackgroundEndoscopic retrograde cholangiopancreatography (ERCP) is a critical therapeutic modality for bile duct stones; however, cases of cystic duct stones (CDS) managed by ERCP alone are rarely reported. Herein, we pr...

HER2-low breast cancer, defined as immunohistochemistry (IHC) 1+ or 2+ with negative in situ hybridization (ISH), has emerged as a clinically relevant therapeutic subgroup. We report the case of a 40-year-old woman with ...

Abstract Background Serum beta-human chorionic gonadotropin is routinely measured as a pregnancy marker in women of reproductive age prior to diagnostic and therapeutic interventions. Although a positive result commonly ...