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81 resultados encontrados.

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Molecular and spatial heterogeneity of macrophage like vascular smooth muscle cells in abdominal aortic aneurysms associated with intraluminal thrombus
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Molecular and spatial heterogeneity of macrophage like vascular smooth muscle cells in abdominal aortic aneurysms associated with intraluminal thrombus
Xiaoying Ma et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Abdominal aortic aneurysm (AAA) is a common cardiovascular disease resulting in high mortality rate due to rupture. Intraluminal thrombus (ILT) is involved in AAA progression via both biomechanically protective ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Molecular factors involved in skin dryness in diabetic patients
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Molecular factors involved in skin dryness in diabetic patients
Joanna Narbutt et al · Termedia Publishing House · 2016 · ISSN 0033-2526
Diabetes is a chronic systemic disease affecting 8.3% of the general population, thus constituting an important clinical and financial problem for healthcare systems throughout the world. Complications of diabetes damage...
LCC LCC:Medicine; LCC:DermatologyIdioma eng
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Piperlonguminine inhibits hen egg white lysozyme amyloid fibril formation and mitigates amyloid fibril–induced hepatocellular damage
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Piperlonguminine inhibits hen egg white lysozyme amyloid fibril formation and mitigates amyloid fibril–induced hepatocellular damage
Gangqiang Liu et al · Elsevier · 2026 · ISSN 2665-9271
Protein misfolding and aggregation into amyloid fibrils (AFs) are critical issues associated with protein stability during food processing and storage, as well as with pathological damage in organisms. Hen egg white lyso...
LCC LCC:Nutrition. Foods and food supply; TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~Idioma eng
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Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers
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Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers
Xiaoyu Yu et al · eLife Sciences Publications Ltd · 2026 · ISSN 2050-084X
A subset of nuclear receptors (NRs) function as permissive heterodimers with retinoid X receptor (RXR), defined by transcriptional activation in response to RXR agonist ligands. Permissive NR-RXR activation is generally ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~; LCC:Biology (General)Idioma eng
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Advanced single-cell transcriptomics deciphers cellular complexity and MIF-orchestrated signaling networks in diabetes-induced myocardial disease
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Advanced single-cell transcriptomics deciphers cellular complexity and MIF-orchestrated signaling networks in diabetes-induced myocardial disease
Zhenyu Lin et al · Elsevier · 2026 · ISSN 2472-6303
Background: Cardiac complications arising from diabetes mellitus manifest as structural and functional myocardial alterations independent of traditional cardiovascular risk factors. The intricate molecular underpinnings ...
LCC TENDOkJpb3RlY2hub2xvZ3k~; TENDOk1lZGljYWwgdGVjaG5vbG9neQ~~Idioma eng
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Aspergillus flavus glutathione transferase as a potential approach for synthesis of epothilone-glutathione conjugates with enhanced anticancer activity for the drug-resistant cells: characterization and molecular docking analysis
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Aspergillus flavus glutathione transferase as a potential approach for synthesis of epothilone-glutathione conjugates with enhanced anticancer activity for the drug-resistant cells: characterization and molecular docking analysis
Ashraf S. A. El-Sayed et al · BMC · 2026 · ISSN 1471-2180
Abstract Epothilone is one of the lead anticancer compounds, with unique binding affinity to the cellular β-tubulin, however, the solubility and efficiency towards the drug-resistant tumors are the challenges. Glutathio...
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Epigenetic signatures and cellular stress response pathways in metabolic dysfunction-associated steatotic liver disease: a personalized medicine perspective
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Epigenetic signatures and cellular stress response pathways in metabolic dysfunction-associated steatotic liver disease: a personalized medicine perspective
Fabian M. Cortés-Mancera et al · Frontiers Media S.A · 2026 · ISSN 1664-042X
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...
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Global Burden of Lead Exposure: Integrating Epidemiology, Molecular Mechanisms, and Mitigation Approaches
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Global Burden of Lead Exposure: Integrating Epidemiology, Molecular Mechanisms, and Mitigation Approaches
Gudisa Bereda · Wiley · 2026 · ISSN 2398-8835
ABSTRACT Background Lead is a nonessential, toxic heavy metal that causes widespread environmental contamination, affecting humans, animals, plants, and ecosystems. Globally, an estimated 800 million children have blood ...
LCC LCC:MedicineIdioma eng
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Integrative machine learning analysis suggests novel molecular targets for liver cancer diagnosis and therapy
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Integrative machine learning analysis suggests novel molecular targets for liver cancer diagnosis and therapy
Fengrui Zhou et al · Springer · 2026 · ISSN 2730-6011
Abstract Background Hepatocellular carcinoma (HCC) is a critical condition characterized by unchecked cellular growth in the liver, often leading to systemic inflammation and organ failure. Although its complex molecular...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions
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Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions
Jingyi Yang et al · Springer · 2026 · ISSN 2662-8651
Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...
LCC LCC:MedicineIdioma eng
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Hedyotis diffusa and Scutellaria barbata enhance the anti-ovarian cancer effect of cisplatin through network pharmacology analysis and molecular docking technology
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Hedyotis diffusa and Scutellaria barbata enhance the anti-ovarian cancer effect of cisplatin through network pharmacology analysis and molecular docking technology
Ran Bi et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Hedyotis diffusa Willd (HD) and Scutellaria barbata D.Don (SB) are widely used traditional Chinese herbs with detoxifying properties and anti-tumor activities. The HD-SB pairing demonstrated significant anti-tum...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Integrated analysis of Morusin inhibiting esophageal cancer via network pharmacology molecular dynamics simulation and in vitro validation
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Integrated analysis of Morusin inhibiting esophageal cancer via network pharmacology molecular dynamics simulation and in vitro validation
Miyuan Yang et al · Springer · 2026 · ISSN 2730-6011
Abstract Esophageal cancer (EC) is a malignant tumor characterized by high incidence and mortality, and its complex pathogenesis necessitates the development of effective therapeutic strategies. In this study, we investi...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Integrating network toxicology and experimental validation to elucidate the molecular mechanism basis of chondrotoxicity of Benzo[a]pyrene in osteoarthritis
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Integrating network toxicology and experimental validation to elucidate the molecular mechanism basis of chondrotoxicity of Benzo[a]pyrene in osteoarthritis
Jingxin Pan et al · Elsevier · 2026 · ISSN 0147-6513
Benzo[a]pyrene (BaP), a widespread environmental pollutant, has been increasingly implicated in the pathogenesis of chronic degenerative diseases. Environmental pollutants have recently been recognized as emerging risk f...
LCC LCC:Environmental pollution; TENDOkVudmlyb25tZW50YWwgc2NpZW5jZXM~Idioma eng
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Shared molecular mechanisms in aging and neurodegenerative diseases: from mechanistic insights to therapeutic strategies
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Shared molecular mechanisms in aging and neurodegenerative diseases: from mechanistic insights to therapeutic strategies
Yesim Kaya et al · Frontiers Media S.A · 2026 · ISSN 1662-5161
Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is chara...
LCC LCC:Neurosciences. Biological psychiatry. NeuropsychiatryIdioma eng
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Deciphering immune and cellular reprogramming during the progression from inflammatory bowel disease to colorectal cancer using multi-omics single-cell and spatial transcriptomics
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Deciphering immune and cellular reprogramming during the progression from inflammatory bowel disease to colorectal cancer using multi-omics single-cell and spatial transcriptomics
Seyed Taleb Hosseini et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Inflammatory bowel disease (IBD) represents a group of chronic and relapsing inflammatory disorders of the gastrointestinal tract, primarily encompassing Crohn’s disease (CD) and ulcerative colitis ...
LCC LCC:MedicineIdioma eng
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Exosome-mediated neuroprotection in vascular dementia: Mechanisms, molecular pathways, and therapeutic prospects
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Exosome-mediated neuroprotection in vascular dementia: Mechanisms, molecular pathways, and therapeutic prospects
Farzaneh Fazli et al · Elsevier · 2026 · ISSN 0890-8508
Exosomes, a specialized class of extracellular vesicles, exhibit significant therapeutic potentials for neurological disorders, in particular for vascular dementia (VaD). VaD is the second most common form of dementia, c...
LCC LCC:Biology (General); LCC:MedicineIdioma eng
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Investigation of Immunostimulatory Effects of Heat-Treated Lactiplantibacillus plantarum LM1004 and Its Underlying Molecular Mechanism
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Investigation of Immunostimulatory Effects of Heat-Treated Lactiplantibacillus plantarum LM1004 and Its Underlying Molecular Mechanism
Won-Young Bae et al · Springer Nature · 2022 · ISSN 2636-0772
Abstract Postbiotics are defined as probiotics inactivated by heat, ultraviolet radiation, sonication, and other physical or chemical stresses. Postbiotics are more stable than probiotics, and these properties are advant...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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An up-to-date review on water-soluble tomato concentrate (Fruitflow®) and healthy ageing: roles of its bioactive compounds and mechanism of action
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An up-to-date review on water-soluble tomato concentrate (Fruitflow®) and healthy ageing: roles of its bioactive compounds and mechanism of action
Amit Dey et al · Elsevier · 2026 · ISSN 1756-4646
Ageing is a complex biological process marked by gradual functional decline, reduced cellular resilience, and increased vulnerability to chronic diseases. Maintaining cell health has become a crucial strategy for extendi...
LCC LCC:Nutrition. Foods and food supplyIdioma eng
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Plasma proteome-wide Mendelian randomization reveals multi-ancestry drug targets for gastric cancer
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Plasma proteome-wide Mendelian randomization reveals multi-ancestry drug targets for gastric cancer
Peng Zhi et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
BackgroundGastric cancer (GC) exhibits marked epidemiological differences between European (EUR) and East Asian (EAS) populations, with significantly higher incidence rates in EAS. Circulating proteins represent promisin...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Genetic Correlation of miR-423 Polymorphism rs8067576 with Progression and Prognosis of Triple-Negative Breast Cancer
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Genetic Correlation of miR-423 Polymorphism rs8067576 with Progression and Prognosis of Triple-Negative Breast Cancer
Pan H et al · Dove Medical Press · 2026 · ISSN 1179-1314
Hailing Pan,1,* Zixin Huang,2,* Aiping Li,1 Meiya Li,3 Yanxing Li,1 Ya Lin,1 Jiayin Cai1 1Department of Oncology, Traditional Chinese Medical Hospital of Wenling Affiliated to Zhejiang Chinese Medical Uni...
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Multi-omics integration and Mendelian randomization elucidate the PARP16–UPR axis driving chemoresistancein gastric cancer
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Multi-omics integration and Mendelian randomization elucidate the PARP16–UPR axis driving chemoresistancein gastric cancer
Shuchang Tao et al · Frontiers Media S.A · 2026 · ISSN 2234-943X
BackgroundAcquired resistance to cisplatin-based chemotherapy is common in patients with gastric cancer (GC) and significantly limits treatment efficacy. The aim of this study was to investigate molecular features associ...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Single-cell and spatial transcriptome analysis reveals the potential therapeutic targets for testicular sex cord-stromal cell tumor
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Single-cell and spatial transcriptome analysis reveals the potential therapeutic targets for testicular sex cord-stromal cell tumor
Lei Chen et al · BMC · 2026 · ISSN 2050-7771
Abstract Testicular sex cord stromal tumor (TSCST) is a rare testicular tumor with unknown molecular mechanisms, tumor microenvironment (TME) and limited therapeutic options. To define the molecular mechanism and potenti...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Intermittent fasting inhibits ferroptosis by modulating CD36 and its palmitoylation to alleviate diabetic dry eye
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Intermittent fasting inhibits ferroptosis by modulating CD36 and its palmitoylation to alleviate diabetic dry eye
Wenhui Wang et al · BMC · 2026 · ISSN 1689-1392
Abstract Background Excessive lipid accumulation in the lacrimal glands under diabetic conditions can lead to lacrimal gland dysfunction and reduced tear secretion, subsequently resulting in ocular surface inflammation, ...
LCC LCC:CytologyIdioma eng
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Prolonged social isolation promotes depressive-like behavior in male and female mice, with sex-related differences in the stress response
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Prolonged social isolation promotes depressive-like behavior in male and female mice, with sex-related differences in the stress response
Yamila Cepeda et al · BMC · 2026 · ISSN 2042-6410
Abstract Background Social isolation is a chronic psychological stressor with high translational relevance to depression in humans, particularly in the aftermath of the COVID-19 pandemic. However, few preclinical studies...
LCC LCC:Medicine; TENDOlBoeXNpb2xvZ3k~Idioma eng
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