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BackgroundWestern diet (WD) consumption accelerates the development of metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). This study investigated whether chestnut-derived ellagitannins (FT50) modulate early m...

Abstract Background Bacterial diseases include any illness caused by bacteria. Bacteria are tiny microorganisms that can only be seen with a microscope. Other types of microorganisms include viruses, fungi, and some para...

Chest X-ray (CXR) interpretation is essential for diagnosing pulmonary diseases, yet manual reading remains slow and prone to human error, especially in high-volume or resource-limited settings. To address delayed diagno...

Abstract Background Acute hepatic porphyria (AHP) is a heme metabolism disorder characterized by acute abdominal pain episodes, with diagnostic delays and misdiagnosis due to heterogeneous presentations and symptom overl...

Background and aim: Angina pectoris is a clinical syndrome usually characterized by episodes or paroxysms of pain or pressure in the anterior chest. The cause is insufficient coronary blood flow, resulting in a decreased...

Abstract Background Blood eosinophil count is an accepted biomarker for type 2 inflammation in COPD. However, the majority of COPD patients are characterized by non-type 2 inflammation. We aimed to test readily obtainabl...

BackgroundFibrinous bronchitis, also known as plastic bronchitis, is a rare airway disorder characterized by branching bronchial casts that replicate the architecture of the bronchial tree. Adult cases are uncommon and f...

ABSTRACT Background and Aims Heparin‐binding protein (HBP) has the potential clinical utility in the early diagnosis and prognosis evaluation of infectious diseases. We aimed to assess the early diagnostic value of HBP...

Cardiovascular diseases remain the leading cause of mortality worldwide, making accurate and efficient imaging-based diagnosis indispensable. Modern modalities such as Coronary Computed Tomography Angiography, Cardiac Ma...

Shape Manifestation of Respiration in the Axial System The aim of the study was to evaluate the effect of respiration on the shape changes of the axial system. Our approach focuses more on the analysis of respiratory fu...

Introduction Tuberculosis (TB) is a global public health threat and a leading cause of morbidity and mortality. To reduce long-term TB burden and address related diseases in Chuuk, Federated States of Micronesia, a commu...

A 12-day-old full-term (FT) male presented with one day of diarrhea and respiratory distress. The exam was notable for hypothermia, tachycardia, and hypoxemia. Initial bloodwork showed leukopenia (3,400 cells/uL, absolut...

Abstract Background Pediatric connective tissue disease-associated interstitial lung disease (CTD-ILD) is a rare but serious condition with limited clinical data; this study aimed to evaluate its clinical features, treat...

IntroductionSystemic juvenile idiopathic arthritis-associated lung disease (sJIA-LD) is a rare, potentially fatal complication of sJIA, often accompanied by pulmonary hypertension (PHTN) and macrophage activation syndrom...

Background: Ankylosing spondylitis (AS) frequently produces thoracic-cage deformities-kyphosis and rib fusion-that restrict chest expansion and impair ventilation, occasionally progressing to atelectasis or pulmonary fib...

We present the case of a 43-year-old male who presented to pulmonology with 3 years of chronic cough and recurrent sinopulmonary infections. He was diagnosed with bronchiectasis and found to have mild thrombocytopenia an...

Interferon regulatory factor-2-binding protein-2 (IRF2BP2) is a transcriptional regulator affecting diverse cellular functions, including cell differentiation and apoptosis. It plays an important role in lymphocyte and m...

BackgroundX-linked hyper-IgM syndrome (XHIM) due to CD40L deficiency typically presents in early childhood with recurrent sinopulmonary or opportunistic infections, and its initial manifestations can be misleading. We re...

Background: The COVID-19 pandemic disrupted TB diagnosis due to overlapping symptoms, healthcare system strains, and changes in healthcare seeking behaviors. Our study aimed to examine factors contributing to delayed TB ...

Abstract Background Pulmonary cryptococcosis (PC) is increasingly diagnosed in human immunodeficiency virus (HIV)-negative and apparently immunocompetent individuals. A critical complication of PC is dissemination to the...

IntroductionSporotrichosis is an uncommon but emerging opportunistic infection in immunocompromised patients. Primary pulmonary sporotrichosis can disseminate and result in significant morbidity and mortality, despite tr...

Abstract Objective Voriconazole is a commonly used antifungal medication, particularly for treating invasive pulmonary aspergillosis and as prophylaxis in hematologic malignancies. However, it can cause adverse effects, ...

Abstract Background People living with HIV (PLHIV) have a higher risk of developing stage 3–5 of Chronic Kidney Disease (CKD) and this risk is further impacted by the use of antiretrovirals including Tenofovir disoprox...

We are reporting a 14-year-old male who presented at 12 years of age with recurrent episodes of hypothermia and bradycardia (30s) secondary to culture-negative septic shock from presumed viral respiratory illnesses. His ...