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BackgroundIdentifying factors predictive of relapse in patients with alcohol use disorder (AUD) following a period of abstinence and/or treatment is essential to discover effective treatment plans for this disease. Previ...

Abstract The mechanisms by which core clock components are spatially organized to ensure robust oscillations in mammals remain unclear. Here, we identify the positive limb factor BMAL1 as a phase-separating protein that ...

Abstract Alcoholic Heart Disease (AHD) involves gut microbiota dysbiosis, metabolic disturbances, and circadian disruption, yet their interconnections remain unclear. Using a murine AHD model, we integrated echocardiogra...

Circadian rhythms are generated by endogenous pacemakers that rely on transcriptional-translational feedback mechanisms conserved among species. In Drosophila, the stability of a key pacemaker protein PERIOD (PER) is tig...

OBJECTIVE: The effect of uric acid and obesity on diurnal blood pressure variation in hypertensive patients is unknown. We aimed to investigate the specific relationship between uric acid, obesity and nocturnal dipping s...

OBJECTIVE: The prevalence of atherosclerosis and osteoporosis increase with age. An association has been demonstrated between cardiovascular diseases and low bone mineral density. We aimed to investigate the association ...

Circadian rhythms are essential for maintaining intervertebral disc (IDD) homeostasis and regulate cellular metabolism, mechanical responses, and therapeutic efficacy. Core clock genes, especially CLOCK and BMAL1, have c...

Abstract Background Bright Light Therapy is effective in improving sleep and circadian rhythms. However, little is known regarding the effects of BioDynamic Lighting. The current study examined whether BioDynamic Lightin...

Volatile sulfur compounds (VSCs) oral dihasilkan dari produk putrifikasi mikroba gas hidrogen sulfida (H2S), metil merkaptan (CH3SH) dan dimetil sulfida [(CH3)2S] yang merupakan gas utama penyebab halitosis. Ritma circa...

Giulia Cera,1 Serena Scarpelli,1,2 Silvamaria Mastrocola,3 Margherita Boltri,3 Federico Brusa,4 Alberto Scalia,4 Maurizio Gorgoni,1,2 Carolina Lombardi,5,6 Leonardo Mendolicchio,4,* Luigi De Gennaro1,* 1D...

The temporal dynamics in biological systems displays a wide range of behaviors, from periodic oscillations, as in rhythms, bursts, long-range (fractal) correlations, chaotic dynamics up to brown and white noise. Herein, ...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

Systemic low doses of the endotoxin lipopolysaccharide (LPS) administered at CT15 (circadian time 12 corresponds to locomotor activity onset) induce phase delays of locomotor activity rhythms in mice. To evaluate if this...

Abstract The Response Regulator (RR) gene family functions as a molecular “switch” in plant signal transduction, with TOC1 (PRR1) frequently acting as a transcriptional repressor that integrates both internal and ext...

BackgroundWe have developed a mouse model of Parenteral Nutrition Associated Cholestasis (PNAC) in which combining intestinal inflammation and PN infusion results in cholestasis, hepatic macrophage activation, and transc...

Abstract Melatonin plays a key role in circadian regulation, and its interaction with the gut microbiota may be critical for early-life development. Beyond its circadian function, melatonin dysregulation is implicated in...

Abstract Abnormal eating habits among young female students were associated with sedentary life-styles and circadian-rhythm disruption, contributing to impaired sleep quality, reduced cognitive performance, and menstrual...

Abstract Objective Based on the bidirectional communication mechanism of the gut-brain axis, this study aims to systematically elucidate the interactive pathways between gut microbiota and insomnia, review the research p...

Exercise promotes neurogenesis and enhances memory consolidation while reducing the retention of aversive memories and anxiety-like behaviors. While our previous work found that acute exercise alters neurotransmitter con...

ObjectiveTo investigate the association between night shift work and chronic kidney disease (CKD) risk and evaluate the interacting role of genetic susceptibility.MethodsThis prospective cohort study included 252,425 par...

Economic demand has modified the temporal organization of work and established the system of shift work. The inability of the individual worker to maintain an adequate quantity and quality of sleep after a day of shift w...

Objectives: The Night Eating questionnaire (NEQ) is regarded as an important tool for the assessment of the severity of the Night Eating Syndrome. The objective of this study was to validate a new Brazilian Portuguese ve...

ObjectiveDelayed sleep-wake phase disorder (DSWPD) is commonly seen in bipolar disorder (BD). However, valid screening tools for DSWPD have not been available, especially in China. Therefore, this study aimed to explore ...

Objective: To describe circadian disruptions in septic patients and their relation to clinical outcome. Methods: In this work we performed an individual analysis of hemodynamic variables (cardiac frequency and mean blood...