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Circadian rhythms are generated by endogenous pacemakers that rely on transcriptional-translational feedback mechanisms conserved among species. In Drosophila, the stability of a key pacemaker protein PERIOD (PER) is tig...

Abstract The mechanisms by which core clock components are spatially organized to ensure robust oscillations in mammals remain unclear. Here, we identify the positive limb factor BMAL1 as a phase-separating protein that ...

Abstract Alcoholic Heart Disease (AHD) involves gut microbiota dysbiosis, metabolic disturbances, and circadian disruption, yet their interconnections remain unclear. Using a murine AHD model, we integrated echocardiogra...

Circadian rhythms are essential for maintaining intervertebral disc (IDD) homeostasis and regulate cellular metabolism, mechanical responses, and therapeutic efficacy. Core clock genes, especially CLOCK and BMAL1, have c...

Giulia Cera,1 Serena Scarpelli,1,2 Silvamaria Mastrocola,3 Margherita Boltri,3 Federico Brusa,4 Alberto Scalia,4 Maurizio Gorgoni,1,2 Carolina Lombardi,5,6 Leonardo Mendolicchio,4,* Luigi De Gennaro1,* 1D...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

BackgroundIdentifying factors predictive of relapse in patients with alcohol use disorder (AUD) following a period of abstinence and/or treatment is essential to discover effective treatment plans for this disease. Previ...

Systemic low doses of the endotoxin lipopolysaccharide (LPS) administered at CT15 (circadian time 12 corresponds to locomotor activity onset) induce phase delays of locomotor activity rhythms in mice. To evaluate if this...

Abstract The Response Regulator (RR) gene family functions as a molecular “switch” in plant signal transduction, with TOC1 (PRR1) frequently acting as a transcriptional repressor that integrates both internal and ext...

Abstract Background Bright Light Therapy is effective in improving sleep and circadian rhythms. However, little is known regarding the effects of BioDynamic Lighting. The current study examined whether BioDynamic Lightin...

Exercise promotes neurogenesis and enhances memory consolidation while reducing the retention of aversive memories and anxiety-like behaviors. While our previous work found that acute exercise alters neurotransmitter con...

Objective: To describe circadian disruptions in septic patients and their relation to clinical outcome. Methods: In this work we performed an individual analysis of hemodynamic variables (cardiac frequency and mean blood...

Objectives: An association, responsible for affecting circadian rhythms and sleep homeostasis, between PER3 gene variable number tandem repeat (VNTR) and sleep times has been described in humans. The aim of this study wa...

Abstract Background Proper eating/fasting cycle can regulate circadian rhythms, thereby influencing metabolic regulation, oxidative stress, and cognitive function. However, its association with overall health remains und...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

Daily morphological variations have been previously described in the viscacha (Lagostomus maximus maximus) retina. The aim of this work was to determine the effects of lithium administration on the histology of retinas f...

BackgroundNumerous studies indicated inflammatory bowel disease (IBD) patients suffered from sleep disturbances. Although melatonin (MT) exerts positive effects on maintaining circadian rhythms and anti-inflammation, its...