Buscar recursos académicos

The early postoperative period in infants following the correction of congenital heart defects is often accompanied by hemodynamic lability, systemic stress, and an acute-phase response, which may lead to transient organ...

Aim: Redox-oxidative dysregulation is implicated in the aetiology of several diseases, including schizophrenia, with a possible influence on clinical symptoms. This study investigated the influence of redox, lipid peroxi...

BackgroundCurrent prognostic models for cerebral venous sinus thrombosis (CVST) inadequately predict long-term cognitive and functional outcomes, focusing primarily on survival. We aimed to develop and validate a simple,...

Sepsis remains one of the most complex and lethal syndromes in pediatric critical care, driven by dysregulated and heterogeneous host responses to infection. Despite decades of biomarker research, few biomarkers have bee...

Category: Ankle, Basic Sciences/Biologics Keywords: Achilles Tendon Rupture, Achilles Tendon, Achilles Tendon Repair Introduction/Purpose: Peroneal tendon disease (PerTD) is a major cause of lateral ankle pain, including...

Abstract Background Outcomes after curative-intent sarcoma surgery vary substantially and are incompletely explained by tumor-centered factors alone. Although CT-based body composition metrics provide objective host-rela...

Abstract Background Bipolar disorder (BD) typically emerges during adolescence and is associated with substantial functional impairment, but objective physiological markers are scarce. The niacin skin flushing response (...

ObjectiveTo identify sleep-disordered breathing phenotypes in older adults with depressive disorder and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate their associations with systemic inflammation.Meth...

Abstract Background Down syndrome (DS), a prevalent chromosomal disorder, is generally characterized by distinctive facial features and congenital anomalies. Transient abnormal myelopoiesis (TAM) is a transient myeloprol...

Abstract Background Lymphocytosis is relatively common in cats, but few studies describe lymphocyte populations or the clinical course associated with different immunophenotypic expansions. Hypothesis/Objectives We hypot...

Kai Chen,1,* Yiqing Nong,1,* Ying Liu,2 Ziming Ye3 1Department of Neurology, Guangxi Medical University Kaiyuan Langdong Hospital, Nanning, 530023, People’s Republic of China; 2Department of Rehabilitat...

Abstract BackgroundCardiovascular magnetic resonance (CMR) is widely used across various cardiac conditions and systematically assesses cardiac anatomical structures and functional dynamics. Machine learning ...

Abstract Background Human patients with Ehlers‐Danlos syndrome (EDS) are categorized into subtypes based on causative genetic variants and phenotypes. The classical form of EDS, primarily caused by variants in COL5A1 o...

Abstract Purpose Triple-negative breast cancer (TNBC) displays an aggressive clinicopathological profile. Despite cytotoxic chemotherapy being the primary systemic therapy, complete responses are achieved in fewer than 3...

Spinocerebellar ataxia type 8, a debilitating neurological disease with no effective treatment, is caused by a CAG•CTG expansion mutation. In SCA8 mice, metformin decreases repeat-associated non-AUG proteins and neuroi...

Abstract Background Discordance between small dense low-density lipoprotein cholesterol (sdLDL-C) and low-density lipoprotein cholesterol (LDL-C) levels is common. Whether this easily calculated parameter, derived from r...

Abstract Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid progression and poor prognosis. This study integrates bioinformatics with experimental validation to cha...

Children with epilepsy frequently experience a range of significant comorbidities beyond seizures, such as motor dysfunction, cognitive impairment, and neurodevelopmental delays. In some cases, these comorbidities contri...

Abstract Background Blood eosinophil count is an accepted biomarker for type 2 inflammation in COPD. However, the majority of COPD patients are characterized by non-type 2 inflammation. We aimed to test readily obtainabl...

ObjectiveTo examine the prevalence of cognitive impairment and factors associated with cognitive impairment among elderly patients with schizophrenia, and to explore potential clinical phenotypes using a clustering appro...

Abstract Certain human mutations in the mitochondrial aldehyde dehydrogenase 4A1 (ALDH4A1) lead to a severe, paediatric form of epilepsy and developmental abnormalities, yet the precise molecular mechanism leading to the...

Abstract Clinicians often view exposure to supplementary oxygen in preterm infants as a simple reciprocal trade‐off between mortality and the risk of vision‐threatening retinopathy, but this perspective oversimplifie...

Abstract Chimeric antigen receptor (CAR) T cell therapies have achieved clinical success in autologous treatment of hematological malignancies. However, their broader application remains limited. Beyond the biological ch...

Abstract Precise extraction of medical phenotypes and entities from electronic health record (EHR) text is vital for numerous clinical research tasks, including cohort classification, tracking temporal patterns in diseas...