Buscar recursos académicos

Recent advances in Alzheimer’s disease research have reshaped how clinical trials are designed and interpreted, particularly through the use of targeted monoclonal antibodies, biomarker-guided enrollment, and novel dru...

Background Conduction system pacing (CSP) has emerged as an alternative to right ventricular pacing (RVP) for atrioventricular block (AVB) aiming to avoid ventricular dyssynchrony and adverse heart failure outcomes yet c...

ObjectiveApproximately half of common variable immunodeficiency (CVID) patients develop debilitating and life-threatening clinical manifestations of immune dysregulation, including lymphoproliferation, cytopenias, inters...

Abstract Precise placement of orthodontic mini-implants (OMIs) in the anterior palate, particularly in the median and paramedian regions, is essential for reliable skeletal anchorage. Digitally planned insertion guides m...

Abstract Backgrounds Clinical trials are central in pandemic preparedness and response (PPR). This scoping review aimed to illustrate the landscape of COVID-19-related randomized controlled trials (RCTs), focusing on the...

BackgroundPivotal clinical trials form the evidentiary foundation for FDA oncology drug approvals, yet persistent disparities in participant demographics may limit the generalizability and equity of cancer care. This stu...

The therapeutic efficacy of Mesenchymal Stromal Cells (MSCs) has been demonstrated in a multitude of pre-clinical studies and clinical trials, yet the translation of MSC therapies is limited by biological factors such as...

Abstract Background and objectives The under-representation of vulnerable groups in clinical trials, including persons with disabilities, could affect the applicability of trial findings to real-world public health inter...

Abstract Background Regulatory barriers present significant challenges to clinical trial approval during both “peacetime” and pandemics, particularly for multi-country clinical trials sponsored by academic institutio...

Background and purpose: Deviations in radiotherapy quality can significantly affect clinical trial outcomes, including overall survival. Radiotherapy quality assurance (RTQA) is a systematic process by which a RT plan is...

Abstract The application of Bayesian statistics in pivotal clinical trials has gained increasing attention, particularly for underpowered confirmatory trials such as those in pediatric and rare disease populations. Bayes...

ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and...

Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with rising global prevalence. Current management strategies predominantly address behavioral symptoms rather than core neurobi...

Abstract Knee osteoarthritis (KOA) is a degenerative joint condition characterized by progressive cartilage deterioration and chronic pain, leading to functional impairment. Bone marrow-derived orthobiologics, such as bo...

ObjectiveTo evaluate the efficacy and safety of skull base-peripheral (SBP) acupuncture in patients with post-stroke cognitive impairment (PSCI).MethodsWe searched eight Chinese and English databases from inception to Ju...

Introduction and aims: Early clinical exposure (ECE) integrates students into clinical settings during theoretical learning, aiming to foster professional development. This systematic review aims to comprehensively evalu...

Introduction: Online Gambling Disorder is an increasingly prevalent behavioral addiction frequently accompanied by depressive symptoms and significant functional impairments. Despite growing clinical recognition, pharmac...

Pregnant women, particularly those in the first trimester, have been historically excluded from clinical trials, resulting in substantial evidence gaps for the prevention and treatment of malaria in early pregnancy. Desp...

Abstract Background Subjective cognitive decline and mild cognitive impairment represent critical windows for intervention as early stages of dementia progression. Although digital health interventions have shown potenti...

Abstract Background Large language models (LLMs) are increasingly used by the public to seek health information, including explanations of medical treatments and clinical trials. Objective The objective of this study was...

Successful completion of industry-sponsored clinical trials requires effective collaboration between sponsors and clinical research sites recruiting patients. As pharmaceutical companies specialize in more therapy areas,...

ABSTRACT Background Multiple sclerosis (MS) is the most prevalent immune‐mediated neurodegenerative disease affecting the central nervous system. Ocrelizumab, a humanized anti‐CD20 monoclonal antibody, has demonstrat...

The incidence and mortality rates of breast cancer are increasing, although improvements in traditional treatments, and it remains the most frequent cancer among women globally. The increasing demand for natural suppleme...

ABSTRACT Background and Aims Propolis is a natural resinous substance produced by bees, recognized for its antioxidant and anti‐inflammatory properties. Previous clinical trials have reported inconsistent results regar...