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The temporal dynamics in biological systems displays a wide range of behaviors, from periodic oscillations, as in rhythms, bursts, long-range (fractal) correlations, chaotic dynamics up to brown and white noise. Herein, ...

ABSTRACT The rapid advancement of medicine, fueled by big data and interdisciplinary research, has significantly transformed the landscape of computational oncology research. In this evolving environment, effective time ...

The rapid expansion of whole-genome sequencing (WGS) has highlighted the important contribution of noncoding variants to human disease, yet their pathogenic mechanisms remain difficult to resolve. Traditional statistical...

Abstract Background N6-methyladenosine ( $$m^{6}A$$ ) plays a crucial role in enriching RNA functional and genetic information. While deep learning has advanced $$m^{6}A$$ site identification, current state-of-the-art me...

In recent years， quantitative microbial risk assessment （QMRA） for food safety has developed rapidly both domestically and internationally. QMRA integrates multidisciplinary theoretical knowledge and technical meth...

Abstract The latent features of RNA sequences are crucial for our understanding of their functions. Thus, Transformer-based nucleotide language models have received widespread attention; however, the O(n²) complexity of...

Stimulated Raman scattering (SRS) microscopy is a fast Raman imaging technique that combines the molecular specificity of vibrational spectroscopy with the high spatial resolution and speed of laser-scanning microscopy. ...

Abstract Actions are the building blocks of our dynamic visual world, yet the neural computations supporting action perception are not well understood. How does perceptual and conceptual information unfold in the brain w...

A common feature in biological neuromuscular systems is the redundancy in joint actuation. Understanding how these redundancies are resolved in typical joint movements has been a long-standing problem in biomechanics, ne...

Tumor growth involves a dynamic interplay between cancer cells and host cells, which collectively form a tumor microenvironmental network that either suppresses or promotes tumor growth under different conditions. The tr...

Abstract Human social behaviors involve complex interactions between individuals, and understanding how interbrain neural activity reflects and predicts these interactions is critical for advancing social cognitive neuro...

Abstract Cognition is supported by neuronal signaling between regions of the cerebral cortex, most of which are linked by a strong synapse in the thalamus, forming transthalamic pathways. These pathways have gained atten...

Abstract Cell–cell communication regulates complex biological processes in multicellular systems. Existing scRNA-seq-based methods typically aggregate gene expression by clusters, overlooking within-cluster heterogenei...

Background: Deep learning has transformed medical imaging by enabling earlier and more accurate disease diagnosis. Lesion and tumor segmentation, essential for analyzing and tracking morphological changes, is commonly do...

Social determinants of health (SDOH) are the conditions in which people live, work, and play, and the wider set of factors (e.g., social and economic systems and policies) that shape a person's daily life. SDOH can diffe...

Protein structure determines biological function. Accurately conceptualizing 3D protein/ligand structures is thus vital to scientific research and education. Virtual reality (VR) enables protein visualization in stereosc...