Buscar recursos académicos

Abstract Chronic wounds represent a longstanding clinical problem due to impaired angiogenesis due to insufficient activation of vascular endothelial growth factor receptor 2 (VEGFR2). In this investigation, we used comp...

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in which immune dysregulation and metabolic remodeling are common features. Laminin subunit alpha 3 (LAMA3), a component of lamini...

The rapid expansion of whole-genome sequencing (WGS) has highlighted the important contribution of noncoding variants to human disease, yet their pathogenic mechanisms remain difficult to resolve. Traditional statistical...

ABSTRACT Bio‐inspired optimisation methods have been widely applied to complex real‐world problems, particularly in low‐carbon power and energy systems, where optimisation tasks often involve high‐dimensional, co...

Background The long-term biological effects of low-level exposure to artificial sweeteners remain debated. We integrated computational toxicology and Mendelian randomization (MR) to explore potential biological responses...

Abstract Fewer than one thousand cataloged mechanistic annotations can be found in the open literature and databases. Here, we introduce MechFind, a computational tool that generates element and charge-balanced putative ...

Abstract A Schiff base ligand L 1 was synthesized via the condensation reaction between from 2-hydroxy-1-naphthaldehyde and 4-methoxyaniline. This Schiff base was employed for the preparation of metal complexes of type [...

Abstract Background N6-methyladenosine ( $$m^{6}A$$ ) plays a crucial role in enriching RNA functional and genetic information. While deep learning has advanced $$m^{6}A$$ site identification, current state-of-the-art me...

Context. Astronomical environments are governed by a complex interplay of physical processes, including gravitational dynamics, radiative transfer, stellar evolution, chemistry, and hydrodynamics. These processes span a ...

Introduction. The performance reliability of electric vehicles (EVs) is an important factor in evaluating their suitability for widespread adoption. The reliability and lifespan of an EV depend on several critical factor...

Abstract Alkaline water electrolysis represents a promising pathway for green hydrogen production, yet comprehensive multi-physics simulation remains computationally prohibitive for practical design optimization. This st...

Foothold selection for hexapod robots in complex terrain presents a significant challenge, demanding both high computational efficiency and robust adaptability. To address this issue, this paper introduces a foothold sel...

Abstract Advances in AI have transformed the traditional Internet of Things (IoT) into smarter, more versatile next-generation devices. Enhanced connectivity among sensors, actuators, and appliances boosts data availabil...

Soft robotics is a rapidly evolving field that leverages compliant and deformable materials to create robotic systems capable of safe human interaction, environmental adaptability, and bio-inspired motion. Unlike rigid r...

ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...

This study presents the application of an enhanced Proportional–Integral–Derivative (PID)-like Sliding Mode Controller (SMC), referred to as the Integral PID-like Sliding Mode (IPS) controller, for cruise control sys...

Nonlinear response conception in rotating machinery, particularly in systems with squeeze film dampers (SFDs), pose significant challenges for established time-domain numerical methods due to bifurcations and critical po...

IntroductionThis article investigates the linguistic and computational challenges of detecting antisemitism in digital communication, integrating discourse-analytical and artificial intelligence (AI) perspectives. It con...

Reconstructing the early spatiotemporal dynamics of emerging infectious diseases (EIDs) is essential for effective public health response but remains difficult due to reporting delays, heterogeneous surveillance systems,...

Abstract Facial Expression Recognition (FER) demonstrates significant value in practical scenarios such as intelligent human–computer interaction. However, conventional FER methods often struggle to balance performance...

As a key element of human settlements and fundamental features in maps, buildings play a critical role in urban planning and environmental monitoring. Automatically extracting buildings from remote sensing images is of s...

The RAG1 and RAG2 genes encode proteins essential for initiating V(D)J recombination in T cell receptor and immunoglobulin gene loci. Biallelic pathogenic variants in these genes are implicated in a spectrum of immunodef...

Fungi are ubiquitous across nearly all habitats and play pivotal roles in maintaining ecological sustainability. Understanding the composition and functional roles of active fungal communities is essential for elucidatin...

INTRODUCTION: Accurate power quality disturbances (PQDs) classification is critical for maintaining grid stability and reliability in modern power systems. However, existing deep learning methods predominantly rely on si...