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Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cholinergic dysfunction, making acetylcholinesterase (AChE) a key therapeutic target. Although Garcinia kola has been widely reported ...

Novel innovations in large language models (LLMs) have demonstrated their ability to generate and analyze literary texts. As a result of intricate semantic layers, metaphors, polyphony, and nonlinear narrative structures...

It is very essential to predict the flow and its related parameters to understand real life fluid flow. The real-life fluid problems are studied with wind tunnels which gives very efficient results in practice. But in th...

Sepsis remains one of the most complex and lethal syndromes in pediatric critical care, driven by dysregulated and heterogeneous host responses to infection. Despite decades of biomarker research, few biomarkers have bee...

Abstract Liver cirrhosis represents a progressive vascular and metabolic disease, which results due to chronic inflammatory injury to the tissues and presents with aberrant tissue regeneration, fibrosis with nodular conf...

Abstract Ventricular shunt catheters are the standard of care for managing hydrocephalus, yet 40% of implanted catheters fail within two years of implantation, mainly due to proximal catheter obstruction. Prior literatur...

To address the challenges of aviation safety information overload in Pre-flight Information Bulletin (PIB) systems, this study proposes an intelligent classification framework (ERNIE-DPCNN) that integrates knowledge-enha...

Visual attention in interpretive settings is shaped not only by image saliency but also by the context viewers receive before viewing. However, how different context formats relate to attention allocation in curated visu...

Abstract The research article reports a simple strategy through Vilsmeier Haack formylation for the synthesis of ethyl 1-formyl-1,2,3,6-tetrahydro-4-methyl-2-oxo/thioxo-6-phenylpyrimidine-5-carboxylates. The most facile ...

"A label-free molecular imprinted polymer (MIP) sensor was fabricated for the detection of progesterone in aqueous solutions, by polymerization inside the void spaces of colloidal crystals, which gave them photonic prope...

This work studies the performance of two open-source CFD codes, OpenFOAM and MFiX, to address bubbling fluidized bed system at different temperature and heat transfer conditions. Both codes are used to predict two parame...

Abstract Computational efficiency and accuracy always conflict with each other in molecular dynamics (MD) simulations. How to enhance the computational efficiency and keep accuracy at the same time is concerned by each c...

The P300 component of event-related potentials (ERPs) is widely used in the implementation of brain computer interfaces (BCI). In this context, one of the main issues to solve is the binary classification problem that en...

Abstract State-supported research funding agencies are critical to the scientific enterprise. However, it remains unclear how funding agencies cooperate with academic communities to realize common scientific goals. Here,...

Abstract Spatial variations in stiffness and mass density make the free-vibration behavior of tridirectionally functionally graded material (3D-FGM) beams highly sensitive to material gradation, while computationally eff...

Abstract Background Optimization of biotechnological processes is traditionally limited by time-consuming trial-and-error approaches and the complexity of simultaneously optimizing multiple, often conflicting objectives....

Traditional malware detection techniques frequently fail to detect and stop malicious activity in an era where cyber threats are becoming more complex. Any software that enters a computer system without the administrator...

The complement system is a blood-based immune network that plays a crucial role in fighting infection and maintaining immune homeostasis. The membrane attack complex (MAC) is a pore assembled from complement proteins tha...

IntroductionThe current paper suggests the conceptualisation of surveillance federalism as the theoretical framework to interrogate the recomposition of local and regional democratic autonomy in the context of multi-leve...

Abstract Silver nanoparticles show promise anticancer agents, yet their clinical translation is hindered by poor bioavailability and nonspecific toxicity. In this study, we developed an apigenin-functionalized silica-coa...

ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...

Background Cognitive–behavioural theories of panic disorder posit that panic attacks arise from a positive feedback loop between arousal-related bodily sensations and perceived threat. In a recently developed computati...

Abstract Modern antenna design is an intrinsic undertaking. It relies heavily on expert knowledge and computational tools, especially electromagnetic (EM) simulation software. The most daunting phase is the development o...

This paper proposes an innovative automated multiphysics Microelectromechanical systems (MEMS) co-optimization platform integrating the embedded reduced-order modeling offered by Coventor MEMS+ with MATLAB’s numerical ...