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Prenatal testosterone (T) excess increases ovarian follicular recruitment, follicular persistence, insulin resistance, and compensatory hyperinsulinemia. Considering the importance of insulin in ovarian physiology, in th...

Developmental plasticity, the ability to regulate aspects of development in response to environmental cues, is hypothesized to evolve in response to environmental heterogeneity and may facilitate dispersal, novel habitat...

ABSTRACT Although the issue of temporality has mainly been studied from Physics, this topic also exhibits diverse interesting aspects that could be addressed from a biological perspective. One possible way of approaching...

Elucidation of the cellular functions of RNAs represents one of the most exciting research areas in modern life sciences. RNAs play crucial roles in plant biology, including developmental regulation and environmental res...

Cestode development involves complex morphological and physiological changes. Here, we performed a differential expression analysis of gene transcripts between two developmental stages of the model cestode Mesocestoides ...

As the twentieth century neared its midpoint, paleoanthropology was in dire need of revitalization and some coherent concept of evolution.  Sadly, as introduced to paleoanthropology by Ernst Mayr in 1950, the Modern Evo...

Abstract High-throughput omics technologies have transformed our understanding of female reproductive biology, revealing molecular interactions governing oocyte maturation, ovarian reserve, endometrial receptivity, and e...

Whilst common across the animal kingdom, the evolution of cannibalism remains poorly understood. Part of the problem is that the number of taxonomic groups in which the evolution of cannibalism has been studied in detail...

El objetivo del presente trabajo es indagar la naturaleza integradora de la biología evolutiva del desarrollo (evo-devo). En particular analizamos las características temporales de los procesos estudiados por diferen-t...

Background - Plants in over one hundred families in habitats worldwide bear extrafloral nectaries (EFNs). EFNs display a remarkable diversity of evolutionary origins, as well as diverse morphology and location on the pla...

Hoyeraal-Hreidarsson syndrome (HHS) represents the most severe form of dyskeratosis congenita (DC), a telomere biology disorder caused by pathogenic variants in genes involved in telomere maintenance. DKC1 encodes dysker...

Alpha-ketoglutarate (AKG) is an important intermediate in Krebs cycle and in metabolism of amino acids. Recently, it was proposed to apply as a dietary supplement to improve overall functional state of living organisms. ...

T follicular helper (Tfh) cells have been reported to have multiple trajectories, including terminally differentiated Tfh, memory-like circulatory Tfh (cTfh), and, most recently, induced T follicular regulatory (iTfr) ce...

Craniofacial morphogenesis is a highly coordinated developmental process governed by complex genetic and molecular interactions. Among these, the PAX family of transcription factors plays a pivotal role in the regulation...

ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contribut...

ABSTRACT Genus Eimeria is a group of obligate Protista parasites within phylum Apicomplexa that causes a major threat to animal production. Little information is available about the coccidia of pigeons. This study was un...

The extended evolutionary synthesis (EES) emphasizes integrative approaches to understanding distributed adaptability, incorporating development and intergenerational effects, inclusive inheritance and niche construction...

In this study, the authors show that treatment with acetyl-carnitine can ameliorate learning and memory defects and hyperactivity in a mouse model of the cognitive disorder, Arboleda–Tham syndrome. Pathogenic variants ...

Abstract Tumor-associated macrophages can either promote or suppress cancer, but therapeutic targeting remains challenging because we lack a predictive framework for macrophage function. The prevailing M1/M2 paradigm ove...

Abstract Background Polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome is a rare autosomal recessive mTORopathy caused by biallelic STE20‐related kinase adaptor alpha (STRADA) loss‐of‐function...

Morphological phenotyping of genetically engineered or experimentally challenged mice is the first step in researching the causality of congenital malformations. Especially for spatially complex structures like the inner...

Abstract Background The floral transition in maize represents a pivotal developmental switch that determines flowering time, environmental adaptation, and yield-related traits. However, the molecular mechanisms governing...

Lissencephaly type 10 (LIS10, OMIM#618873) is a rare neurodevelopmental disorder characterized by posterior-predominant pachygyria/agyria or subcortical band heterotopia on brain imaging. Clinically, affected individuals...

Abstract Cell differentiation is a complex process characterized by specific gene expression patterns regulated through enhancer-promoter interactions within the three-dimensional architecture of the nucleus. The precise...