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Abstract This study aimed to determine the dynamics of natural infection in the transmission of Babesia spp. to cattle in an enzootic instability area in Northeastern Brazil. Blood samples were collected from 30 calves l...

Environmental factors such as air pollution, weather events, and ambient toxins are major contributors to human disease, with disproportionate impacts on vulnerable populations. In Puerto Rico, chronic exposure to air po...

Abstract Background Cardiovascular diseases (CVDs) continue to be the leading cause of mortality worldwide, accounting for approximately 19.8 million deaths in 2022, with ischemic heart disease and stroke responsible for...

Abstract Background Social mixing studies provide crucial evidence for parameterizing mathematical models of infectious disease transmission, and their validity for use in models is dependent on their study design and ho...

In this paper, we construct and analyze a mosquito-borne disease model with chemotaxis in a homogeneous environment. Different from traditional modes that mosquitoes disperse with local diffusion, we correlate the chemot...

BackgroundObesity is a major risk factor for lipotoxic cardiomyopathy, a process involving lipid metabolism disorders, inflammatory responses, and mitochondrial dysfunction. Salvia miltiorrhiza (Danshen), a traditional C...

IntroductionAlzheimer’s disease (AD) is strongly associated with cerebrovascular dysfunction and impaired glymphatic clearance. These dysfunctions may precede, contribute to, and interact bidirectionally with AD pathol...

Reconstructing the early spatiotemporal dynamics of emerging infectious diseases (EIDs) is essential for effective public health response but remains difficult due to reporting delays, heterogeneous surveillance systems,...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cholinergic dysfunction, making acetylcholinesterase (AChE) a key therapeutic target. Although Garcinia kola has been widely reported ...

Background: Barrett's esophagus (BE) represents a critical precancerous lesion arising from chronic gastroesophageal reflux disease (GERD), with significant risk of progression to esophageal adenocarcinoma. Despite advan...

Abstract Background Phylodynamics, the study of the interaction between epidemiological and pathogen evolutionary processes within and among populations, was originally defined in the context of rapidly evolving viruses ...

Abstract Background Axial spondyloarthritis (axSpA) is commonly treated with tumor necrosis factor-alpha (TNF-α) inhibitors, which show good efficacy but may cause adverse effects or lose effectiveness over time. Interl...

Ziyuan Shen,1 Xing Xing,2 Kang Rong,3 Ziyang Geng,4 Ning Yang,5 Linyan Xu,3,6 Hongfeng Ge,7 Wei Sang3,6,8 1Clinical Research Institute, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Re...

ABSTRACT Transition metal ions have been implicated in modulation the conformational behavior and aggregation of WT α‐synuclein (WT‐αSyn), associated with Parkinson's disease pathology. Nevertheless, the initial st...

Abstract Objectives To analyze spatiotemporal clustering patterns of severe hand foot and mouth disease (HFMD) in children aged ≤ 5 years, quantify the associations between meteorological factors and severe HFMD in...

Yuan Cui,1,2 Jingyi Hu,1 Yanan Li,1 Yiheng Tong,1 Hong Shen1 1Department of Gastroenterology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001,...

The Nipah virus (NiV) is a zoonotic pathogen known for causing severe illnesses in both animals and humans, including encephalitis and respiratory issues. In this study, we present a nonlinear system of ordinary differen...

Kiwifruit soft rot caused by fungal pathogens can result in substantial postharvest losses. While Alternaria alternata and A. tenuissima have been implicated in this disease, their pathogenic mechanisms remain poorly cha...

Sudden death syndrome (SDS) is a major disease that affects soybean (Glycine max) production, primarily caused by the soilborne fungus Fusarium virguliforme in North America. Understanding the interactions among soybeans...

BackgroundRecessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis caused by biallelic COL7A1 mutations, where chronic inflammation drives disabling complications affecting quality of life and su...

This paper presents an innovative parallel computational methodology employing adaptive fractional differential operators to address Monkeypox epidemiological modeling challenges. The complex dynamics of such models ofte...

The early postoperative period in infants following the correction of congenital heart defects is often accompanied by hemodynamic lability, systemic stress, and an acute-phase response, which may lead to transient organ...

Abstract High-throughput analysis of EEG data has significantly contributed to understanding neural dynamics in Alzheimer’s disease diagnosis. However, the complexity and high dimensionality of EEG signals pose challen...

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition characterized by hepatic fat accumulation and systemic metabolic dysfunction. MASLD exhibits clear sex differenc...