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Abstract Breast cancer remains one of the most prevalent malignant tumors affecting women worldwide and continues posing a major threat to global health. Current clinical treatments include surgery, chemotherapy, radioth...

With the widespread application of chemotherapy, immunotherapy, and targeted therapy, cardiotoxicity associated with anti-tumor treatment has gained increasing attention. Drug-induced cardiac injury can significantly imp...

Abstract Background The global rise of extensively drug-resistant Acinetobacter baumannii, particularly biofilm-forming strains, has drastically limited treatment options and created an urgent need for novel therapies to...

Materias / palabras clave: accomplishment; chemoinformatics; computer-aided drug design; impact factor; metric; science practitioners

ObjectiveGlucagon-like peptide-1 (GLP-1) receptor agonists have emerged as a therapeutic strategy for reducing drug craving and intake. However, their efficacy in methamphetamine use disorder remains unexplored. This stu...

Abstract Background Curcumin is one such polyphenol that has low bioavailability as well as solubility. Therefore, the present study has analyzed, investigated, and estimated the antimicrobial, antioxidant, and anticance...

The frequent rise of antibiotic-resistant bacteria is due to the increasing use of antibiotics in the healthcare system. Probiotics could offer a potential alternative, although their efficacy tends to be diminished in t...

Abstract The rapid emergence of multidrug-resistant (MDR) bacteria poses a critical challenge in hospital-acquired infections, particularly methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Antimicrobial pept...

Aging is an irreversible and natural phenomenon. At the biological level, aging is caused by various molecular and cellular damages over time. Evidence of Anti-aging were observed in Yeast, Worms and Mice with metformin....

Background. Viral infections remain a major global health threat despite advances in vaccines and antiviral drugs due to the rapid emergence of resistance and new viral pathogens. Antiviral peptides (AVPs) are promising ...

BackgroundGlioblastoma (GBM) remains a lethal brain tumor with limited therapeutic options and near-universal recurrence. Drug repurposing offers a practical strategy, but pleiotropic compounds require systematic target ...

Abstract The advancement of sustained-release drug delivery systems is profoundly reshaping the medicinal applications. This study highlights a novel approach to developing sustained-release esterase responsive drug deli...

Zi-Xiu Gou, Ning-Wei Li, Jun-Yi Yao, Yun-Liang Wang Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence: Yun-Liang Wang, Departme...

Abstract Quality defects in substandard medicines represent a threat to public health. Rapid and accurate identification of these defects is critical to prioritise the cases and implement regulatory measures. However, th...

Abstract Background EUPATI Spain and EURORDIS have implemented a patient engagement model in health product research and development (R&D): international, independent Community Advisory Boards (CABs), where patients coll...

Chronic limb-threatening ischemia (CLTI) represents the most severe form of peripheral artery disease, with high risks of infection, tissue loss, amputation, and mortality. Continuous or high-frequency monitoring could i...

B cell-mediated immunity plays a crucial role in long-term humoral protection. However, dysregulation of B cell development and differentiation may lead to the persistence of autoreactive clones, contributing to autoimmu...

Parkinson’s disease (PD) is characterized by profound metabolic disturbances in the brain, yet how these alterations vary across brain regions and respond to neuroprotective intervention remains poorly understood. Here...

Abstract Background Covalent protein modification by drugs or their reactive metabolites has emerged as an important mechanism underlying pharmacological activity. However, its contribution to the therapeutic effects of ...

Background. Patient hemodynamic stability during general anesthesia is a crucial factor, managing which helps avoid many complications, especially cardiovascular ones. Intravenous and inhaled anesthetics affect the human...

Abstract This study investigates the synthesis and evaluation of glycine-conjugated 5.0G polypropyleneimine dendrimers as an advanced nanocarrier system for the selective delivery of chloroquine. 5.0G PPI dendrimers were...

Abstract Liver fibrosis remains an unmet medical need with limited therapeutic options and high translational failure. Conventional two-dimensional stellate cell cultures and cytokine-induced organoids poorly recapitulat...

Abstract BackgroundMainstays of pharmacoepidemiology are large, representative, behavioral surveys, which focus on many drugs with few detailed behaviors. Smaller, targeted studies measure drug-specific patte...

Abstract Background Gastrointestinal stromal tumors (GISTs) are primarily treated with tyrosine kinase inhibitors (TKIs) such as imatinib. However, the development of drug resistance remains a critical clinical challenge...