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ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...

Pharmaceutical technology has increasingly integrated artificial intelligence (AI) in recent years. This technology offers significant benefits, including saving time and money while enhancing the understanding of the re...

The increasing complexity of pharmaceutical management in pharmacies demands efficient systems to streamline drug classification and inventory control. As pharmacies handle a diverse range of formulations, including tabl...

The history, policies and practice of drug control in Asia have been historically multifaceted, particularly concerning substances like opium, cannabis, and various indigenous psychoactive plants. The opium trade, notabl...

Research for innovative drugs is crucial to contribute to parasitic infections control and eradication. Inspired by natural antiprotozoal triterpenes, a library of 12 hemisynthetic 3-O-arylalkyl esters was derived from u...

The production, distribution, and consumption of drugs has long been seen as a threat to social and economic development. On the other hand, conditions of unemployment and poverty foster expansion of illegal drug markets...

Computer-aided drug discovery and design involve the use of information technologies to identify and develop, on a rational ground, chemical compounds that align a set of desired physicochemical and biological properties...

Artificial intelligence (AI) is increasingly used to design and optimize small molecules. However, most current workflows remain centered on drug-candidate objectives, such as potency, ADMET, and drug-likeness, rather th...

Abstract Parasitic diseases such as malaria, leishmaniasis, and schistosomiasis remain difficult to treat due to the pathogens’ complex life cycles, intracellular niches, and resistance to conventional therapies. Tradi...

To ensure the perennity of natural resources, the valorisation process of herbal pharmaceuticals must be assessed for sustainability from the very beginning of its design. No specific tools have been developed for this p...

"Decision support systems for alert drug-drug interactions have been shown as valid strategy to reduce medical error. Even so the use of these systems has not been as expected, probably due to the lack of a suitable desi...

"Clinical Decision Support Systems can alert health professionals about drug interactions when they prescribe medications. The Hospital Italiano de Buenos Aires in Argentina developed an electronic health record with dru...

Abstract Generative artificial intelligence is reshaping how researchers discover protein-binding compounds and develop them into drug candidates. Unlike traditional methods that screen existing molecules, structure-base...

Benznidazole (1) remains the primary antiparasitic drug used clinically for Chagas disease, underscoring the need to discover novel treatments targeting Trypanosoma cruzi (T. cruzi) infection. In this sense, the present ...

Abstract Background A sustainable and stability-indicating reversed-phase high-pressure liquid chromatography (RP-HPLC) method has been developed for the simultaneous estimation of chlorthalidone (CHL), Amlodipine (AML),...

This commentary discusses the FDA’s drug approvals in 2025, with a particular focus on cancer therapies and the role of companion diagnostics (CDx). Cancer has emerged as the leading therapeutic area, accounting for 35...

The complex etiology and short-term positive effects of treatments for osteoarthritis (OA) remain a significant challenge globally. The lack of approved disease-modifying OA drugs (DMOADs) and the rapid clearance of intr...

Persistent cervical human papillomavirus (HPV) infection is the key biological event underlying high-grade squamous intraepithelial lesions, cervical cancer development, and recurrence risk. Botanical drugs and their bio...

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovial inflammation, progressive cartilage destruction, and bone erosion. Although there have been significant improvements in the use of conventio...

Over 70% of pharmaceutical compounds face the challenge of poor water solubility, which impacts on their bioavailability. This study focuses on the use of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica material as...

This study developed, optimized, and evaluated floating tablets containing Losartan potassium intended to provide prolonged gastric retention for hypertensive patients. HPMC K15M was found to effectively extend drug rele...

Considerable resources have been spent on estimating the size of populations of people who use drugs (PWUD) and people who inject drugs (PWID) in Africa. Precise estimates are elusive, not least because of stigma and cri...

Drug-induced cardiac arrhythmias are central to physiology and pharmacology education, yet students often struggle to connect electrophysiological mechanisms with dynamic electrocardiographic (ECG) changes. We developed ...

Analytical solutions based on the pseudo-steady state approximation (PSSA) were derived for the case of controlled dispersed-drug release from erodible and non-erodible planar matrices, through a membrane, and taking int...