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The objective of the present study was to minimize the unwanted toxic effects of antihypertensive drug diltiazem hydrochloride (DTZ) by kinetic control of drug release from microparticles using chemically modified locust...

In the present study, a simple, rapid and precise liquid chromatographic method was developed and validated for the determination of ezetimibe in its dosage form. Ezetimibe was separated in a 100 x 4.6 mm i.d., C18 colum...

The present investigation concerns the development of mucoadhesive tablets of captopril which were designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated u...

The objective of the present work was to formulate chitosan nanoparticles as carriers for the lovastatin, since this drug undergoes extensive first pass extraction in the liver, and bioavailibity is low (< 5 %). Nanopart...

Effervescent tablets have always been convenient, simple and measured dosage form. The phenomenon of carbonation, in this type of dosage form, accelerates the solubility and enhances the bioavailability of the drug and t...

The purpose of this paper was to produce controlled-release matrices with 120 mg of propranolol hydrochloride (PHCl) employing hydroxypropyl methylcellulose (HPMC, Methocel® K100) as the gel forming barrier. Although th...

A sensitive and specific high performance reversed phase liquid chromatographic method was developed for quantification of citicoline monosodium (CTM) in human plasma. The active drug was isocratically eluted at a flow r...

The present study was undertaken to evaluate the effect of glyceryl monostearate (GMS) and stearic acid (SA) on the release profile of gliclazide from the matrix. Matrix tablets for the controlled delivery of gliclazide ...

The aim of this study was to develop sustained release formulation for improving bioavailability of metronidazole designing metronidazole loaded chitosan microcapsules (MLCM) using coacervation technique. Two solutions w...

The aim of the present research was to build a tool to classify patients according to drug theraphy risk so as to rationalize the use of clinical pharmaceutical resources in hospital settings. Risk factors selected in th...

Papain has been known by many decades for wounded tissues repair. However, papain stability is not high enough to be commercialized in a stable pharmaceutical form; therefore its use is limited. The strategy to entrap pa...

The present investigation concerns the development of floating tablets of tramadol hydrochloride, which after oral administration are designed to prolong the gastric residence time; improves the drug bioavailability, red...

The aim of the present study was to develop sustained release swelling tablets containing metformin HCl and confine them into the stomach for enhancement of bioavailability. The different batches were manufactured by wet...

The aim of the current study was the design, development and optimization of oral immediate release solid dosage forms of gliclazide tablets, intended for rapid action within 30 min, formulated and optimized by in vitro ...

The purpose of the present study was to develop and optimize floating-bioadhesive bilayer gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence ...

We aimed to evaluate the incidence of adverse drug reactions (ADRs) at a hospital, determine the variation in the incidence of ADRs between genders and among age groups, and determine the pharmacological class most often...

The present research work describes comprehensive stress testing of eprosartan mesylate (EM) according to ICH guideline Q1A (R2), and development of a stability-indicating reversed phase ultra performance liquid chromato...

Targeted delivery systems for treatment of Inflammatory bowel disease (IBD) are designed to increase local tissue concentrations of anti-inflammatory drugs from lower doses compared with systemic administration The objec...

The objective of the present study was to develop an oral timed-released press-coated tablet containing theophylline as a model drug. A D-optimal design of experiment was employed to systematically study the effect of te...

The purpose of development oral fast disintegrating drug delivery is not only to give fast relief but also to overcome difficulty in swallowing tablets and capsules, resulting in non-compliance and ineffective therapy. T...

This work is focused on the development of a new particulate drug delivery system using sodium alginate (SA) and modified hydrophobic hydroxyl propyl methyl cellulose (HPMC, 60L grade) containing diclofenac as a model dr...

The objective of reducing analysis time and maintaining good efficiency, there has been substantial focus on high-speed chromatographic separations. Recently, commercially available ultra performance liquid chromatograph...

The present investigation deals with the development of floating matrix tablet containing Ofloxacin, to prolong the gastric residence time, thereby effective in eradication of Helicobacter pylori from the gastric mucosa....

Fifteen 2-[(substituted-benzylidene)-amino]-5-methyl-thiophene-3-carbonitrile (3a-g) and 2-[(substituted-benzylidene)-amino]-4,5-cycloalkyl-thiophene-3-carbonitrile derivatives (4a-h) were synthesized and screened for th...