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Computer-aided drug discovery and design involve the use of information technologies to identify and develop, on a rational ground, chemical compounds that align a set of desired physicochemical and biological properties...

Intracellular levels of cyclic nucleotide second messengers are regulated predominantly by a large superfamily of phosphodiesterases (PDEs). Most of the different PDE variants play specific physiological functions; in fa...

Membrane transporters play a central role in protecting the body from xenobiotics (either by preventing their absorption, limiting their distribution, or promoting their elimination). Transporters can also participate in...

Several mathematical models in SARS-CoV-2 have shown how the target cell model can help to understand the spread of the virus in the host and how potential antiviral treatments can help to control the virus. Concepts as ...