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Abstract Background Ciprofol is increasingly used for endoscopic sedation due to its reduced injection pain, but evidence regarding its safety when combined with etomidate in elderly patients remains limited. This study ...

ABSTRACT Introduction Upper gastrointestinal endoscopy (UGIE) is a commonly performed procedure for evaluating complaints related to the upper gastrointestinal tract. It serves both diagnostic and therapeutic purposes. O...

Abstract Artificial intelligence (AI) is increasingly used in gastrointestinal endoscopy for polyp detection and classification. However, most AI models are trained on images from multiple video processors, whereas clini...

The majority of patients with cholecystolithiasis are asymptomatic. Hemobilia is a rare complication of cholecystolithiasis. It is also an uncommon cause of upper gastrointestinal hemorrhage, where the source of bleeding...

Abstract Background Neuronal intranuclear inclusion disease (NIID) is a rare and progressive neurodegenerative disorder, distinguished by extreme clinical heterogeneity that frequently results in diagnostic delays. Whil...

Abstract Diagnosis of upper gastrointestinal (UGI) mucosal lesions primarily uses endoscopy. Based on our preliminary work in Zambia which showed that free blood in the stomach was associated with gastric mucosal lesions...

Severe gingival inflammation, which is uncommon in pediatric patients, often indicates underlying systemic conditions. Leukemia, autoimmune diseases, and allergic symptoms can cause gingivitis owing to systemic inflammat...

Abstract Background The recurrence of small intestinal hemorrhage (SIH) poses a significant clinical challenge owing to the absence of reliable and accessible predictive biomarkers. This study aimed to identify a crucial...

Colorectal cancer (CRC) remains a leading cause of global cancer-related morbidity and mortality. The majority of CRC cases arise through two well-established pathways: the conventional adenoma–carcinoma sequence and t...

Introduction and importanceBouveret syndrome is a rare form of gallstone ileus characterized by gastric outlet obstruction secondary to impaction of a gallstone that has migrated into the gastrointestinal tract through a...

Gastric metastases are rare, accounting for only 0.2%–0.7% of gastric malignancies. Gastric metastasis from primary popliteal fossa leiomyosarcoma (LMS) has not been previously reported. We report a 60-year-old female ...

CARMIL2 is a protein required for T cell activation, specifically for CD28 and CARMA-1/PKC coupling and NF-kB signaling. CARMIL2 deficiency has pleiotropic presentations, which can include recurrent viral and mucocutaneo...

X-linked inhibitor of apoptosis (XIAP) is essential for innate and adaptive immune responses, including programmed cell death inhibition, NFkB and MAPK activation, NLRP3 inflammasome activity regulation, and TNFR signali...