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45 resultados encontrados.

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From gene discovery to breeding tools: functional KASP markers for flowering time selection in chickpea
Artículo
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From gene discovery to breeding tools: functional KASP markers for flowering time selection in chickpea
Alejandro Carmona et al · BMC · 2026 · ISSN 1471-2229
Abstract Background Flowering time is a key phenological trait in chickpea (Cicer arietinum L.), determining adaptation to different agro-climatic conditions and directly influencing yield. Here, we investigated the gene...
LCC TENDOkJvdGFueQ~~Idioma eng
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Generative AI in structure-based drug discovery
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Generative AI in structure-based drug discovery
Zhuoya Zhong et al · BMC · 2026 · ISSN 1741-7007
Abstract Generative artificial intelligence is reshaping how researchers discover protein-binding compounds and develop them into drug candidates. Unlike traditional methods that screen existing molecules, structure-base...
LCC LCC:Biology (General)Idioma eng
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Discovery of two new Cystobasidiaceae species (Cystobasidiales, Cystobasidiomycetes) on phylloplane from western China
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Discovery of two new Cystobasidiaceae species (Cystobasidiales, Cystobasidiomycetes) on phylloplane from western China
Peng Wang et al · Pensoft Publishers · 2026 · ISSN 1314-4049
The fungal family Cystobasidiaceae, which includes the genera Begerowomyces, Cystobasidium, Cystastrum, Halobasidium, Robertozyma, and Queiroziella, comprises species that are predominantly associated with plants in trop...
LCC TENDOkJvdGFueQ~~Idioma eng
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Identification of a telomere-aging-related gene as a novel prognostic factor for intrahepatic cholangiocarcinoma: Machine learning-aided biomarker discovery and experimental verification
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Identification of a telomere-aging-related gene as a novel prognostic factor for intrahepatic cholangiocarcinoma: Machine learning-aided biomarker discovery and experimental verification
Jianjian Yin et al · Elsevier · 2026 · ISSN 2472-6303
Background: Intrahepatic cholangiocarcinoma (ICC) is an aggressive hepatobiliary malignancy characterized by a complex pathogenesis and poor prognosis. Telomere dysfunction and cellular senescence are involved in the pat...
LCC TENDOkJpb3RlY2hub2xvZ3k~; TENDOk1lZGljYWwgdGVjaG5vbG9neQ~~Idioma eng
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Causal generalized linear models via Pearson risk invariance
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Causal generalized linear models via Pearson risk invariance
Polinelli Alice et al · De Gruyter · 2026 · ISSN 2193-3685
Prediction invariance of causal models under heterogeneous settings has been exploited by a number of recent methods for causal discovery, typically focussing on recovering the causal parents of a target variable of inte...
LCC LCC:Mathematics; LCC:Probabilities. Mathematical statisticsIdioma eng
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COBT: a gene-based rare variant burden test for case-only study designs using aggregated genotypes from public reference cohorts
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COBT: a gene-based rare variant burden test for case-only study designs using aggregated genotypes from public reference cohorts
Antoine Favier et al · BMC · 2026 · ISSN 1756-994X
Abstract Rare disease gene discovery is limited by small cohorts and the frequent absence of matched controls. We present the Case-Only Burden Test (COBT), a gene-based burden test for case-only designs accounting for mu...
LCC LCC:Medicine; LCC:GeneticsIdioma eng
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A generative explainable model for antimicrobial peptide prediction using bidirectional temporal convolutional neural network
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A generative explainable model for antimicrobial peptide prediction using bidirectional temporal convolutional neural network
Farman Ali et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Advances in artificial intelligence (AI) and multi-omics integration are reshaping precision oncology by enabling deeper mechanistic understanding, improved characterization of tumor heterogeneity, and the accel...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Quantum Computing and Quantum Technologies in Drug Discovery and Therapeutics: Evidence, Benchmarking, and Translational Integration
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Quantum Computing and Quantum Technologies in Drug Discovery and Therapeutics: Evidence, Benchmarking, and Translational Integration
Niazi SK · Dove Medical Press · 2026 · ISSN 1177-8881
Sarfaraz K Niazi Department of Pharmaceutical Sciences, University of Illinois, Chicago, IL, 60612, USACorrespondence: Sarfaraz K Niazi, Email sniazi3@uic.eduAbstract: Quantum technologies—quantum computing, quantum se...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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The potential impact of exosomal miR-484 on post-myocardial infarction angiogenesis using bioinformatics and experimental verification
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The potential impact of exosomal miR-484 on post-myocardial infarction angiogenesis using bioinformatics and experimental verification
Dandan Wu et al · BMC · 2026 · ISSN 1471-2261
Abstract Objective This study aimed to investigate the effect of miRNAs differentially expressed in serum exosomes on endothelial cells after myocardial infarction. Design & methods Specific pathogen-free male Sprague–...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBjaXJjdWxhdG9yeSAoQ2FyZGlvdmFzY3VsYXIpIHN5c3RlbQ~~Idioma eng
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BioOne: a national-scale platform for integrated discovery and utilization of diverse biological resources in South Korea
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BioOne: a national-scale platform for integrated discovery and utilization of diverse biological resources in South Korea
Tae-Ho Kang et al · BioMed Central · 2026 · ISSN 1598-866X
Abstract The rapid growth of biological resources and associated research outputs has increased the complexity of resource discovery, access, and reuse across heterogeneous repositories. However, fragmented metadata sche...
LCC LCC:GeneticsIdioma eng
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Experimental mechanician for plate lattice metamaterial discovery
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Experimental mechanician for plate lattice metamaterial discovery
Songtao Hu et al · Nature Portfolio · 2026 · ISSN 2041-1723
Abstract Plate lattice metamaterials offer higher strength-to-weight efficiency than traditional truss lattices. Their optimization, however, is challenging when having more parameters and multiple objectives. Here, we p...
LCC TENDOlNjaWVuY2U~Idioma eng
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Exploring the biotechnological potential of Amazonian microorganisms through in silico genome analysis for detection of biosynthetic gene clusters
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Exploring the biotechnological potential of Amazonian microorganisms through in silico genome analysis for detection of biosynthetic gene clusters
Eric de Lima Silva MARQUES et al · Instituto Nacional de Pesquisas da Amazônia · 2026 · ISSN 0044-5967
ABSTRACT The discovery of novel bioactive compounds has significant implications for diverse biotechnological applications. However, microbial genomes remain largely underexplored regarding their potential to produce sec...
LCC LCC:Science (General)Idioma eng
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Identification and experimental validation of a circular RNA associated with demethylase genes in maize
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Identification and experimental validation of a circular RNA associated with demethylase genes in maize
A. N. Knyazev et al · Federal Agricultural Research Center of the North-East named N.V. Rudnitsky · 2026 · ISSN 2072-9081
In the context of climate change and the need to reduce pesticide and agrochemical use, the development of sustainable crops is becoming increasingly important. Epigenetic mechanisms, such as histone modifications, allow...
LCC LCC:AgricultureIdioma rus
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Modern Genomics Reshapes Soybean Cyst Nematode Research: Integrating Host Resistance, Nematode Virulence, and Functional Discovery
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Modern Genomics Reshapes Soybean Cyst Nematode Research: Integrating Host Resistance, Nematode Virulence, and Functional Discovery
Esmaeil Miraeiz et al · The American Phytopathological Society · 2026 · ISSN 0894-0282
The soybean cyst nematode (SCN), Heterodera glycines, remains the most damaging pathogen of soybean worldwide. Genomic advances over the past two decades have transformed our understanding of both the nematode and its ho...
LCC TENDOk1pY3JvYmlvbG9neQ~~; TENDOkJvdGFueQ~~Idioma eng
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Molecular and spatial heterogeneity of macrophage like vascular smooth muscle cells in abdominal aortic aneurysms associated with intraluminal thrombus
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Molecular and spatial heterogeneity of macrophage like vascular smooth muscle cells in abdominal aortic aneurysms associated with intraluminal thrombus
Xiaoying Ma et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Abdominal aortic aneurysm (AAA) is a common cardiovascular disease resulting in high mortality rate due to rupture. Intraluminal thrombus (ILT) is involved in AAA progression via both biomechanically protective ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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The Hao-Fountain Syndrome Gene USP7 Restricts Neurotropic Orthoflavivirus Entry via Intrinsic Antiviral Activity
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The Hao-Fountain Syndrome Gene USP7 Restricts Neurotropic Orthoflavivirus Entry via Intrinsic Antiviral Activity
Boris Bonaventure et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Inborn errors of immunity (IEI) can manifest with neurological disorders, indicating genetic overlap between immune and nervous system diseases. However, neurological disorder genes are rarely screened systematically for...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Rediscovery of the endemic and threatened Jewel Damselfly Rhinocypha togeanensis van Tol & Günther, 2018 (Insecta: Odonata: Chlorocyphidae) in Indonesia, with notes on its habitat loss and the urgent need for conservation action
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Rediscovery of the endemic and threatened Jewel Damselfly Rhinocypha togeanensis van Tol & Günther, 2018 (Insecta: Odonata: Chlorocyphidae) in Indonesia, with notes on its habitat loss and the urgent need for conservation action
Muhammad Amiruddin et al · Wildlife Information Liaison Development Society · 2026 · ISSN 0974-7893
Rhinocypha togeanensis van Tol & Günther, 2018 (Insecta: Odonata: Chlorocyphidae) is a damselfly species endemic to Batudaka Island, Togean Archipelago, Indonesia. Since its discovery over 25 years ago, no further recor...
LCC TENDOkVjb2xvZ3k~; LCC:General. Including nature conservation, geographical distributionIdioma eng
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Transcriptomics-guided discovery of Interleukin-6 modulators from Bacillus subtilis metabolites in type 2 diabetes mellitus
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Transcriptomics-guided discovery of Interleukin-6 modulators from Bacillus subtilis metabolites in type 2 diabetes mellitus
Tarsha Muthukumar et al · Frontiers Media S.A · 2026 · ISSN 2673-7647
Type 2 diabetes mellitus (T2DM) is characterized by chronic metabolic dysfunction and low-grade inflammation. This study aimed to identify inflammation-associated molecular targets in T2DM and to computationally evaluate...
LCC TENDOkNvbXB1dGVyIGFwcGxpY2F0aW9ucyB0byBtZWRpY2luZS4gTWVkaWNhbCBpbmZvcm1hdGljcw~~Idioma eng
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Application of Reinforcement Learning Techniques in De Novo Drug Design: A Systematic Literature Review
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Application of Reinforcement Learning Techniques in De Novo Drug Design: A Systematic Literature Review
Masuda Begum Sampa et al · Wiley · 2026 · ISSN 2398-8835
ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...
LCC LCC:MedicineIdioma eng
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Artificial intelligence for small-molecule chemical probe design: why drug-centric models may not transfer cleanly
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Artificial intelligence for small-molecule chemical probe design: why drug-centric models may not transfer cleanly
Renzo Carlucci et al · Frontiers Media S.A · 2026 · ISSN 2674-0338
Artificial intelligence (AI) is increasingly used to design and optimize small molecules. However, most current workflows remain centered on drug-candidate objectives, such as potency, ADMET, and drug-likeness, rather th...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Clinical, neuroimaging, and biomarker profiling of four Alzheimer’s disease pedigrees caused by pathogenic APP variants
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Clinical, neuroimaging, and biomarker profiling of four Alzheimer’s disease pedigrees caused by pathogenic APP variants
Jie-Wen Zhang et al · BMC · 2026 · ISSN 1758-9193
Abstract Background Current understanding of the fluid biomarker profile in early-onset Alzheimer’s disease (EOAD) associated with pathogenic APP variants remains limited. We characterized four EOAD pedigrees carrying ...
LCC LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous systemIdioma eng
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Continuous evolving humanoid for advanced cellular models
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Continuous evolving humanoid for advanced cellular models
Daisuke Shimojo et al · Elsevier · 2026 · ISSN 2472-6303
Drug discovery research faces significant challenges, with around 90 % of candidate drugs failing in clinical trials. Traditional animal models do not always accurately reflect human physiology and pathology, leading to ...
LCC TENDOkJpb3RlY2hub2xvZ3k~; TENDOk1lZGljYWwgdGVjaG5vbG9neQ~~Idioma eng
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Decoding FGFR inhibitor sensitivity in cholangiocarcinoma with interpretable machine learning and cross-platform pharmacogenomic validation
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Decoding FGFR inhibitor sensitivity in cholangiocarcinoma with interpretable machine learning and cross-platform pharmacogenomic validation
Yading Xie et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
BackgroundFibroblast growth factor receptor (FGFR) inhibitors (FGFRis) benefit selected cholangiocarcinoma (CHOL) patients, yet responses remain heterogeneous and are not fully explained by canonical FGFR alterations. Cl...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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A Formal Reconstruction of Interpretive Scarcity
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A Formal Reconstruction of Interpretive Scarcity
Christoph J. MERDES · Babeș-Bolyai University · 2026 · ISSN 2065-9407
The theory of hermeneutical injustice analyzes the wrongs suffered due to deficiencies in the shared interpretive resources of a society. A hermeneutical injustice is diagnosed when individuals of a social type are persi...
LCC LCC:Philosophy (General)Idioma deu
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