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Inborn errors of immunity are a group of genetic disorders caused by mutations that affect the development and/or function of several compartments of the immune system, predisposing patients to infections, autoimmunity, ...

Background. Pediatric abdominal pain accounts for more than 1 million emergency department (ED) visits annually, and appendicitis is the most common surgical emergency. Guidelines recommend ultrasound as the initial imag...

Saliva as a microfluidic system offers numerous advantages for both general and oral health diagnostic and therapeutic procedures since its assembly is quick, stress-free, inexpensive and non-invasive. Moreover, saliva i...

Aim: Emergence delirium (ED) is a common behavioral disturbance during recovery from general anesthesia in pediatric patients. This retrospective observational study aimed to evaluate the effect of intraoperative bispect...

Abstract Background Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is generally milder in children than adults, but concerns remain regarding potential long-term pulmonary sequelae, even in non-pneumonic case...

Abstract Background High-risk infants, particularly those with Cerebral Palsy (CP), face major challenges. Early identification of CP is crucial to reducing the disease burden and initiating early intervention. The Gener...

Abstract Certain human mutations in the mitochondrial aldehyde dehydrogenase 4A1 (ALDH4A1) lead to a severe, paediatric form of epilepsy and developmental abnormalities, yet the precise molecular mechanism leading to the...

Foreign bodies in the external auditory canal (EAC) are a common pediatric emergency, especially in children aged 1–4 years due to exploratory behavior and limited risk awareness. Common objects include beads, toy part...

Introduction: Low-voltage electrical injuries are generally considered low risk but can cause significant thermal injury when current is concentrated through conductive materials. Circumferential neck burns from mobile p...

Abstract. With levels of medicine and pharmacology individualization constantly increasing, the scientific community is becoming seriously concerned about the safety of existing and developing drugs for the pediatric pop...

ObjectiveThis study aims to investigate the correlation between trace element concentrations, 25-hydroxyvitamin D [25(OH)D] levels, and the severity of tic disorders (TD) in children from the Hubei region. Additionally, ...

This article aims at providing a general overview of psychological interventions intended to promote psychological adjustment of children with cancer and their parents. To achieve this goal, we reviewed published article...

BackgroundPivotal clinical trials form the evidentiary foundation for FDA oncology drug approvals, yet persistent disparities in participant demographics may limit the generalizability and equity of cancer care. This stu...

Williams syndrome (WS), also known as Williams-Beuren syndrome, is an autosomal dominant disorder. Although the exact incidence is unknown, it is estimated to occur in approximately 1 in 20,000 live births. The syndrome ...

Background: Viscero-abdominal disproportion is a major limiting factor for primary abdominal wall closure in patients with giant omphalocele. The application of fascial traction has been shown to be an effective strategy...

We report a case of a 14-year-old Asian male who presented with a Salter–Harris Type II injury of the proximal tibial epiphysis and a fibular fracture following a minor mechanism of injury. The patient was emergency tr...

Vitiligo is a chronic depigmenting disorder that imposes a substantial psychological, social, and economic burden, extending beyond its physical manifestations. This narrative review synthesizes and critically evaluates ...

Introduction: Optimal transfusion thresholds in burn patients remain a topic of debate. While liberal strategies aim to improve oxygen delivery, restrictive protocols may minimize transfusion-related risks. Evidence in g...

IntroductionA subset of patients with acute appendicitis presents with complicated disease characterized by periappendiceal abscess. Although appendiceal neoplasms are rare in uncomplicated appendicitis, recent evidence ...

Abstract Background Polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome is a rare autosomal recessive mTORopathy caused by biallelic STE20‐related kinase adaptor alpha (STRADA) loss‐of‐function...

La paquioniquia congenital (PC) es una genodermatosis poco frecuente, caracterizada por presentar queratodermia palmoplantar dolorosa y debilitante, uñas hipertróficas, hiperqueratosis folicular, quistes epidérmicos, ...

Abstract Background Musculoskeletal diseases, such as Juvenile Idiopathic Arthritis (JIA), can lead to altered joint mobility and changes in gait pattern. While marker-based motion capture systems are considered the gold...

Abstract Background The foetus depends on maternal vitamin D status during pregnancy, and the strong correlation between maternal and newborn vitamin D status is well established. However, the long-term tracking of vitam...

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