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Drought stress limits wheat productivity at terminal stage by disrupting physiological activities, impairing cellular homeostasis, and decreasing grain yield. Present study elucidated the role of potassium silicate (K2Si...

Abstract Cartilage and synovium are essential tissues involved in joint-related diseases and traits, including osteoarthritis (OA), rheumatoid arthritis (RA), and human height. Although genome-wide association studies (G...

Craniofacial morphogenesis is a highly coordinated developmental process governed by complex genetic and molecular interactions. Among these, the PAX family of transcription factors plays a pivotal role in the regulation...

Together with the environment, genetic factors can significantly influence sleep and its architecture. Monozygotic twins have greater similarity in terms of latency and duration of sleep cycles than dizygotic twins, in a...

The outer membrane of gram-negative bacteria is a barrier to chemical and physical stress. Phospholipid transport between the inner and outer membranes has been an area of intense investigation and, in E. coli K-12, it h...

Abstract Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or ...

Mycoplasma pneumonia (MP), as a global infectious disease in sheep, seriously affects the production performance of sheep and economic benefits of sheep industry. However, current research on sheep resistance to MP remai...

Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

Abstract Actinidia rufa is a valuable species for hybridization and introgressive breeding of new kiwifruit cultivars due to its exceptional tolerance to waterlogging. In this study, a chromosome-level genome of A. rufa ...

Cardiovascular disease (CVD) represents a significant global public health challenge, with its high incidence and mortality rates imposing a substantial socioeconomic burden. Tribbles family proteins (TRIB1, TRIB2, and T...

Abstract Histone post-translational modifications epigenetically regulate gene expression by modulating nucleosome structure and DNA accessibility. This review outlines how unique patterns of modifications on canonical ...

Abstract Background The genetic architecture of circulating amino acids (AAs) and microbiota-related metabolites (MRMs) in relation to cardiometabolic disease remains poorly characterized in East Asian populations, limit...

Identification of specific genetic markers that determine interbreed differences and “selection signatures” in commercial pig breeds will allow for the development of more effective strategies for targeted breeding a...

Abstract Background Prolificacy is a crucial economic trait in goat production, yet its underlying molecular mechanisms remain incompletely understood due to its polygenic nature. While previous studies have identified s...

Mycobacterium tuberculosis (M.tb.) infection leads to over 1.5 million deaths annually, despite widespread vaccination with BCG at birth. Causes for the ongoing tuberculosis endemic are complex and include the failure of...

Post-traumatic stress disorder (PTSD) is a severe neuropsychiatric disorder characterised by re-experiencing, avoidance and hyperarousal. Memory abnormalities manifested as intrusive thoughts and prolonged distressful em...

Although DNA methylation is the best characterized epigenetic mark, the mechanism by which it is targeted to specific regions in the genome remains unclear. Recent studies have revealed that local DNA methylation profile...

Abstract The liver is a central organ controlling lipid and cholesterol metabolism and plays a key role in regulating lipoprotein profiles and cardiovascular disease risk. Males and females show clear differences in chol...

Abstract Dietary protein plays a crucial role in shaping the gut microbiome and modulating intestinal amino acid metabolism. Gut microbiome is recognized as a reservoir for carrying antimicrobial resistance genes. Howeve...

Brain expression of the enzyme P450-aromatase has been studied extensively. Subsequent to the aromatisation hypothesis having established brain aromatase as a key factor to convert gonadal testosterone to oestradiol, sev...

Coffee is a remarkable source of bioactive compounds, including anthocyanins, proanthocyanidins, and carotenoids, with health benefits. To fully understand the biochemical and molecular regulation mechanisms behind Coffe...

The filtered load of water, electrolytes and toxic substances of human kidney is huge. The largest part of this filtered load must be absorbed by renal tubules. Our understanding of the transport mechanisms, their regula...