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Our past, present, and future are governed by the grand design of the genetic blueprint, which was mapped more than two decades back. While the eloquent design of our genome results from millions of years of evolution a...

ABSTRACT Mycobacterium smegmatis is nonpathogenic and fast-growing and is usually used as a model species of Mycobacterium. Studying basic metabolic mechanisms is crucial for accelerating mycobacterial research. Although...

Polyphenol Oxidases (PPOs) catalyze the conversion of phenolic substrates to quinones, leading to the formation of dark-colored precipitates in fruits and vegetables. This process, known as enzymatic browning, is the cau...

Abstract Human genome-editing is banned by guidelines, laws and regulations in most countries. However, the first criminal case on genome-edited babies was sentenced in China in 2019. In this commentary we discuss our le...

BackgroundOn-demand gene editing of autologous cells offers a novel therapeutic option for inborn errors of immunity (IEIs) caused by dominant-negative variants, which are often poorly addressed by conventional viral gen...

Human induced pluripotent stem cells (iPSCs) are transforming adoptive cell therapy by combining unlimited self-renewal, broad differentiation potential, and high amenability to genome engineering. These attributes make ...

Food texture is increasingly recognized as a determinant of nutritional safety, metabolic regulation, and overall health. However, conventional approaches to texture modification rely primarily on hydrocolloids, mechanic...

Abstract Transcriptional regulation, critical for cellular differentiation and adaptation to environmental changes, involves coordinated interactions among DNA sequences, regulatory proteins, and chromatin architecture. ...

Abstract Among oilseeds crops, Brassica napus L., is of great importance globally. The economic yield and harvest efficiency are significantly limited by seed shattering, which represents a persistent agronomic constrain...

Abstract Dissecting the functional impact of genetic mutations is essential to advancing our understanding of genotype-phenotype relationships and identifying therapeutic targets. Despite progress in sequencing and genom...

ABSTRACT Upstream open reading frames (uORFs) are regulatory elements present in the 5′ leaders of mRNA that can significantly impact downstream gene expression in eukaryotes. In crop engineering, editing of uORFs can ...

IntroductionPennycress (Thlaspi arvense L.) is an emerging intermediate oilseed crop grown in the offseason between primary summer crops to produce three cash crops in two years. Previous efforts to improve seed oil qual...

Genome-wide association studies have identified members of the CARD11/MALT1/BCL10 (CBM) complex as susceptibility loci for common allergic disorders, while carriers with rare loss-of-function (LOF) variants in MALT1 or C...

Abstract Background In photosynthetic eukaryotes of the green lineage, the expression of the chloroplast genome is mainly regulated post-transcriptionally, by RNA-binding proteins encoded in the nuclear genome termed org...

Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by heterogeneity in its genetic, epigenetic, and environmental etiologies, posing significant challenges for therapeutic development...